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Journal of Medicinal Plants and By-products، جلد ۱۳، شماره ۱، صفحات ۱۴۷-۱۵۹
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عنوان انگلیسی Bioactivity and Chemical Profiling of Medicinal Fungi Inonotus cuticularis and Inocutis levis (Hymenochaetaceae) using Chromatography and Mass Spectrometry
چکیده انگلیسی مقاله Polypore fungi are among the most preventable mushroom-forming fungi with known therapeutic potential, though only a few species have been securitized for their metabolites. This study examines the biological activity and bioactive compounds of Inocutis levis and Inonotus cuticularis collected in Iran. We examined the antimicrobial, antioxidant, and cytotoxic properties of n-hexane, acetone, and ethyl acetate extracts. Chemical profiles were assessed by chromatography and mass spectroscopy techniques. The acetonic extracts exhibited the highest antibacterial effect against all tested microbial strains. The IC50 values for DPPH and ABTS assays ranged from 144.98 – 469.02 μg/mL and 128.06 – 331.52 μg/mL, respectively. The MTT assays for both fungi indicated low toxicity on normal HDF cells with IC50 values ranging from 1447 to 1908 μg/mL. HPLC-DAD analysis showed a high level of gallic acid among other detected phenolic compounds. LC-ESI-MS/MS analysis displayed the presence of various sesquiterpenoids, furans, and styrylpyrone-class compounds. Inotilone, inonotin H and C, phellinulin B and M, cinnamic acid, p-coumaric acid, caffeic acid, phelligridin A and D, hispidin, and gallic acid were found in both species. Daedalin A is reported for the first time from the fungal family Hymenochaetaceae. In addition, several volatile compounds, including alkene hydrocarbons and some fatty acids, such as linoleic acid, were detected in GC-MS analyses. We suggest that I. levis and I. cuticularis have dual antibacterial and antioxidant properties and diverse metabolites, potentially opening new windows in future natural product-based medicine.
کلیدواژه‌های انگلیسی مقاله Bioactive compounds, chemical composition, Daedalin A, Hispidin, Polypore fungi, Streptococcus mutans
نویسندگان مقاله Samaneh Chaharmiri-Dokhaharani |
Department of Biotechnology, Iranian Research Organization for Science and Technology (IROST), P. O. Box 3353-5111, Tehran, Iran

Masoomeh Ghobad-Nejhad |
Department of Biotechnology, Iranian Research Organization for Science and Technology (IROST), P. O. Box 3353-5111, Tehran, Iran

Hamid Moghimi |
Department of Microbial Biotechnology, School of Biology, College of Science, University of Tehran, Tehran, Iran

Hooman Norouzi |
Department of Horticultural Sciences, Faculty of Agriculture, Bu-Ali Sina University, Hamedan, Iran

Mohaddeseh Moghaddam |
Department of Biotechnology, Iranian Research Organization for Science and Technology (IROST), P. O. Box 3353-5111, Tehran, Iran

نشانی اینترنتی https://jmpb.areeo.ac.ir/article_128804_f0c108ee8166ae2bc645046299860faf.pdf
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