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Iranian Journal of Public Health، جلد ۵۳، شماره ۱، صفحات ۱۲-۲۴
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عنوان انگلیسی Finding a Link between Obesity and Senescence: A Systematic Review and Meta-Analysis
چکیده انگلیسی مقاله Background: Cell aging is associated with changes in telomeres due to DNA damage arising from chronic inflammation in obese patients. The aim of the systematic review and meta-analysis was to find the relationship between obesity and aging or senescence. Methods: The systematic review was conducted through PRISMA guideline, beginning with literature search within 2012-2022 in several databases (PubMed, EBSCOHost, Science Direct, Scopus, and Cochrane) followed by screening process using predetermined PICO criteria. Original studies on the topic of obesity and senescence (aging), from preclinical studies to clinical research (cohort or cross-sectional studies) that were published within the last ten years. All studies were appraised using SYRCLE risk of bias tool for preclinical studies and Newcastle-Ottawa Scale (NOS) for cross-sectional and cohort studies. The data extraction on the studies’ characteristic and outcome on aging or senescence were followed by quantitative analysis using MetaXL process on prevalence ratio and hazard ratio of obesity to comorbidities and mortality. Results: Fifteen studies were enrolled. Obesity and white adipose tissue cause increased levels of pro-inflammatory and pro-senescence cytokine and macrophage whilst the aging process lowers metabolism with increased insulin resistance and linked to increased risk of obesity. Obesity occurs in 22% (95% CI 18%-26%) of elderly population with higher prevalence rate in the women population. Obesity is associated with significant increased risk of multimorbidity by 56% (OR = 1.58 [95% CI 1.48-1.96]). Conclusion: The obesity and aging or senescence has reciprocal relationship between each other.  
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نویسندگان مقاله | Sry Suryani Widjaja
Department of Biochemistry, Medical Faculty, Universitas Sumatera Utara, Medan, Sumatera Utara, Indonesia


| Rusdiana Rusdiana
Department of Biochemistry, Medical Faculty, Universitas Sumatera Utara, Medan, Sumatera Utara, Indonesia


| Tengku Mardani Helvi
Department of Biochemistry, Medical Faculty, Universitas Sumatera Utara, Medan, Sumatera Utara, Indonesia


| Rostime Simanullang
Department of Nursing School, University of Murni Teguh, Medan, Sumatera Utara, Indonesia


| Vito Filbert Jayalie
Department of Radiation Oncology, Murni Teguh Memorial Hospital, Medan, Sumatera Utara, Indonesia


| Rina Amelia
Department of Community Health, Medical Faculty, Universitas Sumatera Utara, Medan, Sumatera Utara, Indonesia


| Jessie Arisa
Department of Wellness, Murni Teguh Memorial Hospital, Medan, Sumatera Utara, Indonesia
نشانی اینترنتی https://ijph.tums.ac.ir/index.php/ijph/article/view/30855
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