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Biomacromolecular Journal، جلد ۲، شماره ۱، صفحات ۲۱-۲۷
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Association of Polymorphism at 3׳-UTR of Urokinase Gene with Risk of Calcium Kidney Stones |
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| چکیده انگلیسی مقاله |
Urokinase might play a role in the formation of kidney stones. This study was done to determine the association between +4065 T/C polymorphism at the 3′-untranslated region of urokinase gene and calcium kidney stones. This Case-Control study was carried out on 70 cases with a history of calcium kidney stones and 70 controls from the Baqiyatallah hospital of Tehran in 2013. The study of polymorphism was performed by Allele-specific PCR method. Mutant T allele frequency was %41 in cases and %18 in controls. Hardy-Weinberg equilibrium (HWE) was tested using chi-square test. The chi-square showed that the control population is in HWE, and as expected, the patient group does not follow HWE. The odds ratio for the risk of the T allele was 1.7 (%95 confidence interval 0.2988-1.158). A significant association was found between the urokinase gene T/C polymorphism and the formation of calcium kidney stones. Also, effect modification was examined for both sexes and different age groups. According to the results, T polymorphism in the 3’-UTR of urokinase gene may increase with age. |
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| کلیدواژه‌های انگلیسی مقاله |
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| نویسندگان مقاله |
ندا عصاری |
department of cell and molecular biology, kharazmi university
seiedabdolmajid انگجی |
سعید مروتی |
department of molecular and biology, faculty of medical sciences, baghiyatallah university of medical sciences, tehran, iran
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| نشانی اینترنتی |
http://www.bmmj.org/article_21157_4a8b1d25ff62021c47a0121c1d1bfecb.pdf |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/2124/article-2124-297410.pdf |
| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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