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Veterinary Research Forum، جلد ۱۰، شماره ۳، صفحات ۱۸۷-۱۹۲
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Attenuating effects of <i>Mangifera indica</i> leaves ethanolic extract against acetamiprid induced reproductive toxicity in male guinea pigs |
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| چکیده انگلیسی مقاله |
Acetamiprid (ACP) belonging to the neonicotinoid family used against wide array of pests in agriculture and domestic purposes. In this study, we evaluated the attenuating effects of ethanolic extract of Mangifera indica leaves (EEMI) in averting reproductive toxicity caused by ACP in male guinea pigs. Thirty male guinea pigs were randomly assigned to five treatment groups (n = 6). Group 1 (T0) received distilled water orally; group 2 (T0-) was given 80 mg kg-1 of ACP and groups 3, 4 and 5 were treated, respectively, with EEMI at doses of 50, 100 and 200 mg kg-1 plus ACP. After 90 days, the reaction time, sexual organ weights, sperm count, motility and anomalies, spermatozoa with entire plasma membrane, testicular histology, serum testosterone concentration, testicular malondialdehyde (MDA) level, reduced glutathione (GSH) concentration, testicular superoxide dismutase (SOD) and catalase (CAT) activities were assessed. Co-administration of EEMI significantly reduced the reaction time, sperm anomalies and testicular MDA, SOD and CAT levels compared to the T0- group. Co-treatment of EEMI significantly alleviated sperm count and motility, percentage of spermatozoa with the normal plasma membrane, serum testosterone concentration, accessory sex gland weights, and testicular GSH concentrations. The ACP treatment induced cell membrane degradation in the testis and this effect was prevented with the addition of EEMI. In conclusion, ACP negatively affected the animal reproductive function and induced oxidative stress. The addition of EEMI alleviated the toxic effects of ACP on the reproductive function of male guinea pigs. |
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| کلیدواژه‌های انگلیسی مقاله |
acetamiprid,
Guinea pigs,
Mangifera indica,
Oxidative stress,
Reproductive functions |
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| نویسندگان مقاله |
Arthénice Jemima Nounamo Guiekep |
Department of Animal Productions, Faculty of Agronomy and Agricultural Sciences, University of Dschang, Dschang, Cameroon
Augustave Kenfack |
Department of Animal Productions, Faculty of Agronomy and Agricultural Sciences, University of Dschang, Dschang, Cameroon
Ferdinand Ngoula |
Department of Animal Productions, Faculty of Agronomy and Agricultural Sciences, University of Dschang, Dschang, Cameroon
Bertin Narcisse Vemo |
Department of Animal Productions, Faculty of Agronomy and Agricultural Sciences, University of Dschang, Dschang, Cameroon
Kenmeuhe Sidje Nguemmeugne |
Department of Animal Productions, Faculty of Agronomy and Agricultural Sciences, University of Dschang, Dschang, Cameroon
Etienne Pamo Tedonkeng |
Department of Animal Productions, Faculty of Agronomy and Agricultural Sciences, University of Dschang, Dschang, Cameroon
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| نشانی اینترنتی |
http://vrf.iranjournals.ir/article_35909_58b33f445a9604bb358ff29bcc9cca24.pdf |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
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