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Veterinary Research Forum، جلد ۱۲، شماره ۱، صفحات ۱۰۹-۱۱۶
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Effects of liraglutide on sperm characteristics and fertilization potential following experimentally induced diabetes in mice |
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| چکیده انگلیسی مقاله |
The current study was conducted to analyze the dose-dependent effects of liraglutide against the diabetes-induced detrimental impact on sperm parameters and fertilization potential. For this purpose, 42 adult male mice were randomly divided into control (with no intervention) and experimental groups. Next, the experimental group was subdivided into diabetic, 1.20 mg kg-1 liraglutide-received diabetic, 1.80 mg kg-1 liraglutide-received diabetic, 1.20 mg kg-1 liraglutide-received non-diabetic and 1.80 mg kg-1 liraglutide-received non-diabetic groups. All chemicals were administrated subcutaneously. Following 42 days, the animals were euthanized, and sperm samples were collected. The sperm count, motility, viability, DNA integrity, and maturity were analyzed and compared between groups. Moreover, the sperm fertilization potential was investigated by in vitro fertilization (IVF). For this purpose, the preimplantation embryo development at 2-cell, 4-cell, morula, and blastocyst stages was investigated and compared. Observations revealed that diabetes significantly diminished sperm count, motility, viability, chromatin condensation, and DNA integrity percentages versus a control group. On the other hand, 1.20 mg kg-1 and 1.80 mg kg-1 of liraglutide did not improve sperm motility and viability, while ameliorated sperm count and chromatin condensation and DNA integrity in diabetic animals. The diabetic animals represented diminished preimplantation embryo development, which was not altered in liraglutide-received groups. In conclusion, at least in administrated doses, liraglutide could not improve the sperm viability and motility and, via this mechanism, could not induce an appropriate/beneficial effect on IVF outcome. |
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| کلیدواژه‌های انگلیسی مقاله |
Experimental diabetes, Fertilizing potential, Liraglutide, Sperm parameters |
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| نویسندگان مقاله |
Maryam Pourheydar |
Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
Shapour Hassanzadeh |
Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
Mazdak Razi |
Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
Bagher Pourheydar |
Department of Anatomical Sciences, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran
Gholamreza Najafi |
Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
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| نشانی اینترنتی |
https://vrf.iranjournals.ir/article_240926_8765d64f9b4cbd59d29f27ea8b3bc223.pdf |
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| زبان مقاله منتشر شده |
en |
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