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Veterinary Research Forum، جلد ۱۳، شماره ۳، صفحات ۳۷۹-۳۸۵
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Effects of Urtica dioica agglutinin lectin on glycotargeting of the vasculature: an in ovo study on chicken embryo |
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| چکیده انگلیسی مقاله |
The angiogenesis process is a pivotal cellular process involved in both developmental and pathological circumstances. In this study we investigated effect of Urtica dioica agglutinin (UDA), as an unusual phyto-lectin from the chitin-binding protein family, on the angiogenesis of chicken embryos. The UDA was extracted from plant rhizomes and purified by affinity chromatography column. The activity of this lectin was assayed by hemagglutination test on the human RBCs. Anti-angiogenic effect of UDA on the extra-embryonic layer of the chick egg was studied in the different concentrations. Our results showed that the minimum concentration of UDA for agglutination were 48.00 and 15.00 µg mL-1 in macro- and microscopic studies, respectively. Because the number and length of the vessels were dramatically decreased at 100 µg kg-1 of UDA, the lectin had an inhibitory effect on angiogenesis of the embryonic vasculature of the chick. We concluded that UDA might target the vascularization events through binding to GlcNAc-conjugates. More investigations are needed to clarify the angiogenesis-related therapeutic roles of this interesting biomolecule. |
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| کلیدواژه‌های انگلیسی مقاله |
Angiogenesis,animal model,Chicken embryo,Lectin activity,Urtica dioica agglutinin |
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| نویسندگان مقاله |
Esmaeil Samadian |
Department of Molecular and Cell Biology, Faculty of Basic Science, University of Mazandaran, Babolsar, Iran
Abasalt Hosseinzadeh Colagar |
Department of Molecular and Cell Biology, Faculty of Basic Science, University of Mazandaran, Babolsar, Iran
Jahanbakhsh Asadi |
Metabolic Disorders Research Center, Golestan University of Medical Science, Gorgan, Iran
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| نشانی اینترنتی |
https://vrf.iranjournals.ir/article_252990_77004cd4bea0879d94ddcb884f2a69d0.pdf |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
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