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Veterinary Research Forum، جلد ۱۴، شماره ۱، صفحات ۱-۶
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عنوان انگلیسی Evaluation of the relationship between inflammatory reaction and interleukins in ovine pulmonary adenocarcinomas
چکیده انگلیسی مقاله In this study, it was aimed to investigate the association between inflammatory reaction of tumoral microenvironments with interleukin responses in ovine pulmonary adenocarcinomas (OPAs). Material of the study consisted of 26 sheep lung tissue samples being brought to the Pathology Department for routine diagnosis. Cases were collected between years 2009 - 2021; pre-diagnosis was based on clinical symptoms, anamnesis and gross lesion of the lungs. These tissues were designated in two groups as control (n = 6) and OPA (n = 20) groups. Choice of immunohistochemical staining was avidin-biotin peroxidase method. Reverse transcription polymerase chain reaction (RT-PCR) was used to confirm Jaagsiekte sheep retrovirus from paraffin-embedded tissues. On gross examination of OPAs, lesions seen were mostly in the caudal lobes of the lung, 1.00 – 2.00 cm in diameter as gray-white consolidated foci and in microscopic observation, tumor cells showed acinar, papillary or mixed growths. No expressions of interleukin (2 and 8) were observed in the control group. All OPAs cases were positive for interleukins (2 and 8) expressions. A total of eight tissue samples were detected as positives through RT-PCR. In conclusion, in this study, it was determined that interleukin-2 and interleukin-8 were produced from tumor microenvironment elements, especially tumor-associated macrophages, and these interleukins showed pro-inflammatory effects. Interleukins and the inflammatory reaction may promote the development of OPA.
کلیدواژه‌های انگلیسی مقاله Inflammation,Interleukins,Pulmonary adenomatosis,Sheep
نویسندگان مقاله Emin Karakurt |
Department of Pathology, Faculty of Veterinary Medicine, Kafkas University, Kars, Türkiye

Nüvit Coşkun |
Department of Virology, Faculty of Veterinary Medicine, Kafkas University, Kars, Türkiye

Enver Beytut |
Department of Pathology, Faculty of Veterinary Medicine, Kafkas University, Kars, Türkiye

Ömer Faruk Keleş |
Department of Pathology, Faculty of Veterinary Medicine, Van Yuzuncu Yil University, Van, Türkiye

Serpil Dağ |
Department of Pathology, Faculty of Veterinary Medicine, Kafkas University, Kars, Türkiye

Volkan Yilmaz |
Department of Virology, Faculty of Veterinary Medicine, Kafkas University, Kars, Türkiye

Hilmi Nuhoğlu |
Department of Pathology, Faculty of Veterinary Medicine, Kafkas University, Kars, Türkiye

Ayfer Yıldız |
Department of Pathology, Faculty of Veterinary Medicine, Kafkas University, Kars, Türkiye

Emre Kurtbaş |
Health Sciences Institute, Kafkas University, Kars, Türkiye

نشانی اینترنتی https://vrf.iranjournals.ir/article_697939_a3d9dd5d9da717222f57df1547b618d5.pdf
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