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Iranian Journal of Chemistry and Chemical Engineering، جلد ۳۹، شماره ۵، صفحات ۳۵-۴۴
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
4-Halo-N-(5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl)benzamide and Benzothioamide Derivatives: Synthesis and in vitro Anticancer Assessment |
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| چکیده انگلیسی مقاله |
Cancer is a lethal disorder that has caused a serious threat to human health and nowadays there is a crucial need for the development of novel anticancer agents. A new series of 1,3,4-thiadiazole-based compounds were synthesized and evaluated for anti-cancer properties in vitro. The synthesis of 5-(Trifluoromethyl)-1,3,4-thiadiazol-2-amine (3) was carried out via solvent-free conditions and consequently, benzamide (4a-4f) and benzothioamide (5a-5f) derivatives bearing halogen moieties (Cl, F) were synthesized. MTT assay was applied for in vitro cytotoxicity assessment against three cancerous cell lines consist of PC3 (Prostate cancer), HT-29 (Colon cancer), and SKNMC (Neuroblastoma). All tested derivatives exhibited equal or more (IC50 = 3-7 µM) cytotoxic activity than doxorubicin (IC50 = 7 µM) as a reference drug against PC3 cell line. Chlorine containing benzamideas well as benzothioamide derivatives (IC50 = 14-36 µM) were also exerted a higher cytotoxic activity against SKNMC cell line compared to doxorubicin (IC50 = 40 µM). |
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| کلیدواژه‌های انگلیسی مقاله |
Synthesis,1,3,4-Thiadiazole,Anticancer,MTT assay |
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| نویسندگان مقاله |
Ali Reza Aliabadi |
Pharmaceutical Sciences Research Center, Health Institute, School of Pharmacy,
Kermanshah University of Medical Sciences, Kermanshah, I.R. IRAN
Hojat Harasami Neek |
Department of Medicinal Chemistry, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, I.R. IRAN
Yazdan Bahmani |
Pharmaceutical Sciences Research Center, Health Institute, School of Pharmacy,
Kermanshah University of Medical Sciences, Kermanshah, I.R. IRAN
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| نشانی اینترنتی |
https://ijcce.ac.ir/article_38207_873d818b51362e39b3706361c4bdac6e.pdf |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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