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Iranian Journal of Chemistry and Chemical Engineering، جلد ۴۱، شماره ۶، صفحات ۱۸۷۰-۱۸۸۲
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Using Chemometrics Methods for Determination of Aripiprazole and Quetiapine as Antipsychotic Drugs in Pharmaceutical Mixture and Biological Fluid by Spectrophotometry Method Based on Continuous Wavelet Transform and Multivariate Calibration |
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| چکیده انگلیسی مقاله |
In this study, two multivariate calibration methods, including partial least squares (PLS) and principal component regression (PCR), as well as continuous wavelet transform (CWT) along with spectrophotometry technique were developed for the simultaneous analysis of Aripiprazole (ARI) and Quetiapine (QTP) in the pharmaceutical formulation and biological fluid. The linear range of ARI and QTP was 1-3 and 2-10 μg/mL, respectively for the proposed methods. The root means square error (RMSE) of ARI and QTP related to the test set was obtained 0.014, 0.0758, and 0.194, 0.882 for PLS and PCR methods, respectively. Also, the mean recovery of ARI and QTP was 99.95, 100.04%, and 97.38, 98.83% for PLS and PCR models, respectively. Among various families of wavelets in CWT technique, the Coiflet (Coif3) and Symlet (Sym2) families were selected to determine the value of ARI and QTP, respectively. In this method, the Limit of Detection (LOD) and Limit of Quantification (LOQ) values was found 0.0033, 0.0200, 0.2764, 0.3486 μg/mL for ARI and QTP, respectively. The mean recovery values of ARI and QTP in synthetic mixtures for CWT approach were 96.98%, 98.94%, respectively. A one-way analysis of variance (ANOVA) test was applied to compare the results of both mentioned chemometrics models and High-Performance Liquid Chromatography (HPLC) as a reference method. No significant difference was observed between these methods. |
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| کلیدواژه‌های انگلیسی مقاله |
Spectrophotometry,Multivariate calibration,Continuous Wavelet Transform,Aripiprazole, Quetiapine, Biological fluid |
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| نویسندگان مقاله |
Mojdeh Alibakhshi |
Department of Chemistry, North Tehran Branch, Islamic Azad University, Tehran, I.R. IRAN
Mahmoud Reza Sohrabi |
Department of Chemistry, North Tehran Branch, Islamic Azad University, Tehran, I.R. IRAN
Mehran Davallo |
Department of Chemistry, North Tehran Branch, Islamic Azad University, Tehran, I.R. IRAN
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| نشانی اینترنتی |
https://ijcce.ac.ir/article_245375_221f1d6ea259bc391129aa05c33132ce.pdf |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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