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Iranian Journal of Chemistry and Chemical Engineering، جلد ۴۱، شماره ۱۲، صفحات ۴۲۱۳-۴۲۱۹
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Isolation, Structure Elucidation, and Standardization of Suberosin and Glycyrrhizin from Ferulago trifida L. and Glycyrrhiza glabra L. |
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| چکیده انگلیسی مقاله |
Natural products currently often consider starting points in drug discovery, followed by synthetic reforms to increase bioavailability and alleviate side effects. Approximately, fifty percent of the approved drugs by the U.S. Food and Drug Administration (FDA) are inspired by natural products. Glycyrrhizin is a well-known anti-inflammatory component that has been shown to prolong the coagulation time of thrombin and fibrinogen and to increase the duration of plasma recalcification. Suberosin, also known as 7-methoxy-6-prenylcoumarin, belongs to the class of coumarin compounds. The purpose of this article is to purify, identify, and standardize glycyrrhizin and suberosin, from Glycyrrhiza glabra L. and Ferulago trifida L. First, two plants were pulverized and then extracted using a percolator. The extracts were then divided into different fractions by column chromatography and mixed with thin-layer chromatography. Finally, we obtained pure compounds after using column chromatography and thin-layer chromatography. 1H-NMR and 13C-NMR have been used to purify compounds and also the HPLC method was used to standardize these compounds. Glycyrrhizin and Suberosin were extracted from Glycyrrhiza glabra L. and Ferulago trifida L respectively and 1H-NMR 13C-NMR techniques approved the structure of these two compounds, also, standardization of these compounds was correctly done by HPLC. |
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| کلیدواژه‌های انگلیسی مقاله |
Structure elucidation,Glycyrrhizin,Suberosin,Standarztition,Glycyrrhiza glabra L,Ferulago trifida L |
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| نویسندگان مقاله |
Saeed Tavakoli |
Medicinal Plants Research Center, Institute of Medicinal Plants-ACECR, Karaj, I.R. IRAN
Farahnaz Khalighi-Sigaroodi |
Medicinal Plants Research Center, Institute of Medicinal Plants-ACECR, Karaj, I.R. IRAN
Reza Hajiaghaee |
Medicinal Plants Research Center, Institute of Medicinal Plants-ACECR, Karaj, I.R. IRAN
Mahdi Yaghoobi |
Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, Tehran, I.R. IRAN
Reza Ghafarzadegan |
Medicinal Plants Research Center, Institute of Medicinal Plants-ACECR, Karaj, I.R. IRAN
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| نشانی اینترنتی |
https://ijcce.ac.ir/article_249211_e55b80de89cbdd63d98e1c3ef3cbc0a6.pdf |
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| زبان مقاله منتشر شده |
en |
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