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Analytical and Bioanalytical Chemistry Research، جلد ۱۰، شماره ۴، صفحات ۳۷۵-۳۸۵
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| عنوان انگلیسی |
Electropolymerized β-cyclodextrin as an Efficient Recognition Element Toward a Highly Sensitive Electrochemical Sensor for Sumatriptan |
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| چکیده انگلیسی مقاله |
The present study aims to introduce a highly sensitive electrochemical sensor for quantification of trace amounts of Sumatriptan (SUM) in biological fluids. To immobilize a stable nano film of β-cyclodextrin (β-CD) on a glassy carbon electrode (GCE), electropolymerization of monomer was carried out within 0.1 M phosphate buffer with pH 6.0 utilizing cyclic voltammetry to yield polymerized β-CD (pβ-CD). The morphological characterization of pβ-CD/GCE was examined by Field emission scanning electron microscopy (FESEM). The electrochemical redox action of SUM on pβ-CD/GCE was scrutiny studied by cyclic voltammetry and chronocoulometry. The electrochemical parameters including the electron transfer coefficient (α), the standard heterogeneous rate constant (ks), the surface area of the electrode (A), the electron transfer number (n), and the surface coverage (Γ) were estimated to be 0.38, 1.23×10-3 cm s-1, 0.06 cm2, 1, 1.07×10-8 mol cm-2, respectively. At optimized criteria, a substantial enhancement was attained toward the electrooxidation of SUM on the developed electrode compared to the bare GCE, resulting in wide linear ranges of 0.0622.47µM and 2.4752.1µM with a low detection limit of 27 nM. The developed sensor was successfully employed for quantification of SUM in human blood serum and urine samples with good selectivity and acceptable recoveries, proving its utility for further applications as a sensitive and reliable sensor. |
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| کلیدواژه‌های انگلیسی مقاله |
Sumatriptan,Cyclodextrin,Cyclic Voltammetry,Electropolymerization,glassy carbon electrode |
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| نویسندگان مقاله |
Ghasem Karim-Nezhad |
Department of Chemistry, Payame Noor University, Tehran, IRAN 19395-3697
Tohid Mahmoudi |
Department of Chemistry, Payame Noor University, Tehran, IRAN 19395-3697
Sadegh Bayat |
Department of Chemistry, Payame Noor University, Tehran, IRAN 19395-3697
Zeynab Khorablou |
Department of Chemistry, Payame Noor University, Tehran, IRAN 19395-3697
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| نشانی اینترنتی |
https://www.analchemres.org/article_171417_ed1ddd15b7315ab85c757d0e45a9254c.pdf |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
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