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Tanaffos، جلد ۲، شماره ۴(autumn)، صفحات ۴۱-۴۸
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عنوان انگلیسی Evaluation of Safety of Nortriptyline in Patients with Chronic Obstructive Pulmonary Disease
چکیده انگلیسی مقاله Background: Patients with severe chronic obstructive pulmonary disease (COPD) have a poor quality of life and limited life expectancy, frequently resulting in depression that enhances their symptoms. This depressive state might need medical intervention; however, the safety of antidepressant drugs in these patients with poor respiratory function is not clear. Materials and Methods: Thirty-four subjects with concomitant COPD and depression as well as 34 controls with COPD without depression were enrolled in a single blind controlled study. Nortriptyline was prescribed to the first group and placebo to the second. Spirometric and gas analysis findings were compared before and after a three-month course of trial. Results: Pulmonary function tests and gas analysis recordings did not show any deterioration after nortriptyline administration. Two deaths occurred during the study period, one in study group due to respiratory infection and the second in control group because of Pulmonary Thromboembolism (PTE). Conclusion: Nortriptyline is a safe medication to be used in COPD patients when indicated. (Tanaffos 2003; 2(8): 41-48)
کلیدواژه‌های انگلیسی مقاله Chronic Obstructive Pulmonary Disease (COPD),Depression,Tricyclic antidepressant(s),Nortriptyline
نویسندگان مقاله Mohamad Golshan |
Department of Pulmonary Medicine, Isfahan University of Medical Sciences and Health Services, ISFAHAN-IRAN

Tooraj Roushan-Zamir |
Department of Pulmonary Medicine, Isfahan University of Medical Sciences and Health Services, ISFAHAN-IRAN

Moulood Sherkat Masoom |
epartment of Pulmonary Medicine, Isfahan University of Medical Sciences and Health Services, ISFAHAN-IRAN

Asadolah Asadian |
epartment of Pulmonary Medicine, Isfahan University of Medical Sciences and Health Services, ISFAHAN-IRAN

نشانی اینترنتی https://www.tanaffosjournal.ir/article_241522_4ec27221d2d27ca7f910fd6298d2e162.pdf
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