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Tanaffos، جلد ۳، شماره ۲(spring)، صفحات ۲۵-۳۱
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| عنوان انگلیسی |
The Study of Th1/Th2 Cytokine Profiles (IL-10, IL-12, IL-4, and IFNγ) in PBMCs of Patients with Multidrug Resistant Tuberculosis and Newly Diagnosed Drug Responsive Cases |
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| چکیده انگلیسی مقاله |
Background: Multi-drug resistant tuberculosis (MDR-TB), which is a worldwide clinical problem, is associated with high morbidity and mortality, as well as long-term survival of infected immunocompetent patients. In this study, the PPD-induced production of IL-12, IL-10, IFNγ, and IL-4 in peripheral blood mononuclear cells (PBMC) from patients with MDR-TB were investigated and compared with cytokine production capabilities in newly diagnosed, treated cases. Materials and Methods: This study investigated the profiles of IFN-γ, IL-12, IL-10, and IL-4 in response to a purified protein derivative (PPD) in peripheral blood mononuclear cells (PBMC) from 15 HIV negative patients with multidrug-resistant tuberculosis (MDR-TB), 11 newly diagnosed, treated cases and compared those with 10 healthy negative tuberculin reactors as controls. Results: ELISA results showed that the following stimulation with PPD, IFNγ production was significantly increased, whereas IL-10 was significantly reduced in MDR-TB patients compared with PPD negative controls. Production of IL-12 in MDR-TB patients showed elevation, induced by PPD stimulation of their PBMCs. However, MDR-TB patients were similar to healthy negative tuberculin controls in their IL-12 production and there was no statistically significant difference between them. IL-4 was detected to be in very low levels in three groups. Conclusion: In this study MDR-TB patients have no dysregulation in IL-12 or IL-10 production during Mycobacterium tuberculosis infection, and profiles are prone to Th1 cytokines. (Tanaffos 2004; 3(10): 25-31) |
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| کلیدواژه‌های انگلیسی مقاله |
Th1/Th2 cytokine profiles,tuberculosis,MDR-TB |
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| نویسندگان مقاله |
Mehdi Shekar-Abi |
Department of Immunology, Iran University of Medical Sciences and Health Services,
Narges Miandehi |
Department of Immunology, Iran University of Medical Sciences and Health Services,
Seyed Davood Mansoori |
Department of Infectious Disease, NRTILD,
Shaheed Beheshti University of Medical Sciences and Health Services, TEHRAN-IRAN
Masoumeh Tavasoli Fayri |
Department of Immunology, Iran University of Medical Sciences and Health Services,
Mohammad Alibahar |
Department of Immunology, Iran University of Medical Sciences and Health Services,
Aref Amirkhani |
Department of Immunology, Iran University of Medical Sciences and Health Services,
Seyed Mehdi Mirsaeidi |
Department of Infectious Disease, NRTILD,
Shaheed Beheshti University of Medical Sciences and Health Services, TEHRAN-IRAN
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| نشانی اینترنتی |
https://www.tanaffosjournal.ir/article_241503_7547228770c5f96a86f2caee17522b2b.pdf |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
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