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Tanaffos، جلد ۴، شماره ۲(spring)، صفحات ۵۳-۶۰
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عنوان انگلیسی Vitamin A Supplementary Effect on Immunologic Profiles in Tuberculosis Patients
چکیده انگلیسی مقاله Background: The effects of vitamins on human immune system have been well studied. Vitamin A deficiency and its effects on immune system in pulmonary tuberculosis (TB) patients have been established. This study was carried out to evaluate vitamin A supplementary effect on immunologic profile of tuberculosis patients. Materials and Methods: In a double-blind clinical trial, thirty-five patients with confirmed pulmonary tuberculosis were included. The case group received vitamin A injection, 50000 lU, every 10 days for two months along with standard treatment of TB; the control group received only anti-TB drugs. Immunologic profiles including CD3+, CD4+, CD8+, CD4+/CD8+, CD19+, HLA-DR, CD16+56+, and plasma vitamin A as well as nutritional status were assessed in both groups primarily and two months after above-mentioned treatments. Data were analysed using SPSS software version 10. Results: The study showed that there were not significant differences in mean(± SD) of age, body weight, height, body mass index (BMI), fat thickness and vitamin A plasma level between the vit A-receiving and control groups. The mean of peripheral blood CD3+ showed significant increase in patient-control group [71.8 ±7.9 % lymphocytes (after supplementation) compared with 68.3 ±10.7% (before supplementation); p= 0.014.]. This was also true about CD4+ (p= 0.001). CD4+ to CD8+ ratio and the mean of CD19+ showed significant decrease in the patient control group and the vit A-receiving group, respectively (p= 0.002 and p= 0.04, respectively). In contrast, there was an increased significant difference for CD+16+56+ mean in the above-mentioned groups which was more prominent in the vit A- receiving group (p=0.038). The means of HLA-DR and CD8+ did not show significant differences in both groups before and after supplementation. Conclusion: It seems that vitamin A supplementary effects on the quality of lymphocytic markers are remarkable. However, further studies should be performed regarding immunologic response quality. (Tanaffos 2005; 4(14):53-60)
کلیدواژه‌های انگلیسی مقاله tuberculosis,Vit A supplementation,Immunologic profile
نویسندگان مقاله Somayeh Mohammadian |
Department of Nutrition, Tabriz University of Medical Sciences and Health Services

Jalil Baghdadchi |
Department of Nutrition, Tabriz University of Medical Sciences and Health Services

Ali Reza Ostad Rahimi |
Department of Nutrition, Tabriz University of Medical Sciences and Health Services

Shahpour Shahghasempour |
Department of Infectious Diseases

Majid Valiollahpour Amiri |
Department of Infectious Diseases

Foroozan Mohammadi |
Department of Clinical Anatomical Pathology,

Seyed Mehdi Mirsaiedi |
Department of Infectious Diseases,

Ali Akbar Velayati |
Department of Pediatrics, NRITLD, Shaheed Beheshti University of Medical Sciences and Health Services.

نشانی اینترنتی https://www.tanaffosjournal.ir/article_241462_b72f8a8e2c7a2c034bc417783cef1fa0.pdf
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