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Tanaffos، جلد ۵، شماره ۲(spiring)، صفحات ۹-۱۲
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Proliferative Marker in Distinction between Benign and Malignant Mesothelial Proliferations |
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| چکیده انگلیسی مقاله |
Background: Differentiation of benign from malignant mesothelial proliferations is a major problem in the pathology of the serosal membranes, particularly in small biopsy specimen. This study was conducted for the evaluation of proliferative marker for distinction between malignant mesothelioma (MM) and mesothelial hyperplasia (MH). Materials and Methods: Thirty six cases of malignant mesothelioma (MM) with the mean age of 62.94 years (range: 36-80 years, M/F: 3.58) and 22 cases of mesothelial hyperplasia (MH) were evaluated for proliferative status by immunohistochemical (IHC) method with monoclonal antibody, Ki-S5 (Ki-67); the labeling indices (LI) were evaluated. Results: Average count revealed a significant increase in MM as compared with reactive MH (p value <0.0001). Considering a threshold of 9% for ki-67, a sensitivity of 88% and specificity of 94% were resulted. Conclusion: Proliferative marker of Ki-67 can be useful in distinction between malignant mesothelioma and mesothelial hyperplasia (p-value <0.0001). (Tanaffos 2006 5(2); 9-12) |
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| کلیدواژه‌های انگلیسی مقاله |
Mesothelial proliferation,Mesothelioma,Proliferative index,Ki-67,Ki-S5 |
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| نویسندگان مقاله |
Zohreh Mohammad Taheri |
Department of Clinical Anatomical Pathology
Mehdi Mehrafza |
Department of Clinical Anatomical Pathology
Forozan Mohammadi |
Department of Clinical Anatomical Pathology,
Maliheh Khoddami |
Department of Clinical Anatomical
Pathology, Imam Hossein Hospital, Shaheed Beheshti University of Medical Sciences and Health Services, THEHRAN-IRAN
Moslem Bahadori |
Department of Clinical Anatomical Pathology
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| نشانی اینترنتی |
https://www.tanaffosjournal.ir/article_241392_e3fdcc2e4a594600cd50ba2491230caf.pdf |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
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