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Tanaffos، جلد ۱۰، شماره ۱(winter)، صفحات ۸-۱۱
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عنوان انگلیسی Prevalence of Oseltamivir-Resistant 2009 H1N1 Influenza Virus among Patients with Pandemic 2009 H1N1 Influenza infection in NRITLD, Tehran, Iran
چکیده انگلیسی مقاله Background: Oseltamivir-resistant cases were reported during the 2009 pandemic influenza outbreak and therefore, widespread emergence of oseltamivir-resistant 2009 H1N1 virus is imaginable. Underlying medical conditions like immunosuppression increase the chance of oseltamivir resistance. Materials and Methods: In a retrospective cross-sectional study, respiratory tract specimens of confirmed cases of 2009 H1N1 influenza referred to the Masih Daneshvari Hospital were analyzed for presence of H275Y mutation. Results: From November 2009 through March 2010, oseltamivir- resistant 2009 H1N1 infection was observed and confirmed in 4 patients (including 2 immunocompromised patients) by performing H275Y mutation molecular testing. Conclusion: Close monitoring of resistance to neuraminidase inhibitors is essential in tertiary care centers. The H275Y mutation (oseltamivir-resistant genotype) could appear in the absence or presence of selective drug pressure.
کلیدواژه‌های انگلیسی مقاله Pandemic 2009 H1N1 virus,H275Y mutation,Oseltamivir-resistance
نویسندگان مقاله Ahmadreza Moradi |
Virology Research Center,

Seyed Alireza Nadji |
Virology Research Center,

Payam Tabarsi |
Mycobacteriology Research Center

Seyed Mohammadreza Hashemian |
Nursing and Respiratory Health Management Research Center

Majid Marjani |
Mycobacteriology Research Center,

Afsaneh Sigaroodi |
Virology Research Center,

Davood Mansouri |
Clinical Tuberculosis and Epidemiology Research Center,

Mohammadreza Masjedi |
Chronic Respiratory Disease Research Center,

Ali Akbar Velayati |
Pediatric Respiratory Disease Research Center, NRITLD, Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, TEHRAN-IRAN.

نشانی اینترنتی https://www.tanaffosjournal.ir/article_241093_7907d5be5e00035e9361dabd2b29980c.pdf
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