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Tanaffos، جلد ۱۸، شماره ۳، صفحات ۲۳۸-۲۴۳
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Pneumocystis jiroveci Pneumonia in HIV-Positive and HIVNegative Patients: A Single-Center Retrospective Study |
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| چکیده انگلیسی مقاله |
Background: To describe the clinical presentations, treatment regimen, and outcomes of Pneumocystis jiroveci pneumonia (PJP) among immunocompromised patients at King Faisal Specialist Hospital and Research Center in Saudi Arabia. Materials and Methods: In this retrospective cohort study, patients with a laboratory-confirmed diagnosis of PJP were included. Results: During the study, 42 patients with confirmed PJP were identified. Twenty (48%) patients were HIV-infected, while 22 (52%) were HIV negative. The median T-cell count (CD4) was below 50 cells/mL in HIV patients with PJP at the time of HIV and PJP diagnoses. Graft rejection, cytomegalovirus (CMV) reactivation, and lymphopenia were associated with the development of PJP in transplant recipients; and high-dose steroids for non-transplant patients. The allcause mortality at 90 days was lower in individuals with HIV-related PJP, compared to those with other predisposing conditions (10% and 32%, respectively; P=0.085). No specific risk factors were independently associated with the increased risk of mortality. Conclusion: PJP remains an important cause of morbidity and mortality in immunocompromised patients, with a higher mortality rate reported in non-HIV patients. |
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| کلیدواژه‌های انگلیسی مقاله |
PJP,Pneumocystis Jiroveci,PCP,pneumonia,HIV,AIDSdefining condition,Trimethoprim/sulfamethoxazole,Solid organ transplant |
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| نویسندگان مقاله |
Reem S. Almaghrabi |
Department of Medicine, King Faisal Specialist Hospital
and Research Centre, Riyadh, Saudi Arabia,
Sadeem Alfuraih |
Department of Medicine, King Faisal Specialist Hospital
and Research Centre, Riyadh, Saudi Arabia,
Rand Alohaly |
1 Department of Medicine, King Faisal Specialist Hospital
and Research Centre, Riyadh, Saudi Arabia,
Shamayel Mohammed |
Department of Pathology and Laboratory Medicine,
King Faisal Specialist Hospital and Research Centre,
Riyadh, Saudi Arabia,
Abdulrahman A. Alrajhi |
Department of Medicine, King Faisal Specialist Hospital
and Research Centre, Riyadh, Saudi Arabia,
Ali S. Omrani |
Department of Medicine, King Faisal Specialist Hospital
and Research Centre, Riyadh, Saudi Arabia,
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| نشانی اینترنتی |
https://www.tanaffosjournal.ir/article_239978_d6125bd8571f3c9f290d2a982ed4e217.pdf |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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