| چکیده انگلیسی مقاله |
Background: Due to the critical condition of COVID-19, it is necessary to evaluate the efficacy of administrating convalescent plasma to COVID-19 patients. Therefore, we decided to design a clinical trial to investigate the effect of convalescent plasma of patients recovered from COVID-19 on the treatment outcome of COVID-19-infected patients. Materials and Methods: In this parallel randomized controlled clinical trial, patients in the intervention group received standard treatment plus convalescent plasma of patients recovered from COVID-19. We allocated 60 patients to each treatment group through balanced block randomization. Then, COVID-19 outcomes, vital signs, and biochemical parameters were compared between the two treatment groups by the independent t test and ANCOVA. Results: The mean age (SD) of the patients in the intervention and standard treatment groups was 52.84 (15.77) and 55.15 (14.34) years, respectively. Although patients in the intervention group reported more hospitalization days (11.45±5.86 vs. 10.42±6.79), death rates (26.67% vs. 18.13%), ICU admission (45 vs. 41.67%), and ARDS (11.67% vs. 3.33%), these differences were not statistically significant (P>0.05). Moreover, the two groups were homogenous in vital signs and biochemical parameters before and after treatment (P>0.05). Conclusion: The present study indicated that convalescent plasma therapy has no significant effect on the survival, hospitalization, and ICU admission of COVID-19 patients. |
| نویسندگان مقاله |
Ebrahim Jalili |
Department of Emergency Medicine, School of Medicine, Besat Hospital, Hamadan University of Medical Sciences, Hamadan, Iran
Salman Khazaei |
Research Center for Health Sciences, Hamadan University of Medical Sciences, Hamadan, Iran
Afshin Mohammadi |
Blood Transfusion Organization, Hamadan, Iran
Fariba Keramat |
Brucellosis Research Center, Sina Educational and Medical Center, Hamadan University of Medical Sciences, Hamadan, Iran
Seyed Hamid Hashemi |
Brucellosis Research Center, Sina Educational and Medical Center, Hamadan University of Medical Sciences, Hamadan, Iran
Saeid Bashirian |
Social Determinants of Health Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
Toos Kiani |
Deputy of Treatment, Hamadan University of Medical Sciences, Hamadan, Iran
Farid Azizi Jalilian |
Department of Virology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
Samereh Ghelichkhani |
Deputy of Treatment, Hamadan University of Medical Sciences, Hamadan, Iran
Manoochehr Karami |
Modeling of Noncommunicable Diseases Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
Maryam Farrokhi |
Deputy of Research and Technology, Hamadan University of Medical Sciences, Hamadan, Iran
Rashid Heidarimoghadam |
Health Sciences Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
Tahereh Abbasi Garavand |
Department of Internal Medicine, School of Medicine, Shahid Beheshti Medical Educational Center, Hamadan University of Medical Sciences, Hamadan, Iran.
Ebrahim Daneshyar |
Deputy of Treatment, Hamadan University of Medical Sciences, Hamadan, Iran
Mohammad Abbasi |
Department of Internal Medicine, School of Medicine, Shahid Beheshti Medical Educational Center, Hamadan University of Medical Sciences, Hamadan, Iran.
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