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Tanaffos، جلد ۲۲، شماره ۱، صفحات ۱۷۶-۱۸۱
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عنوان انگلیسی Congenital Skin Rashes in an IVF Baby Progressed to Multisystem Langerhans Cell Histiocytosis with Lung and Bone Involvement: A Case Report and Literature Review
چکیده انگلیسی مقاله Langerhans cell histiocytosis is an uncommon proliferative disorder that may influence many organs; so, the clinical presentations vary. Here we describe an 85-day-old female who was born with In vitro fertilization after 10 years of infertility. She referred to us due to severe pulmonary insufficiency and congenital progressive maculopapular rash with desquamation. There were significant cystic changes in chest imaging studies. Further evaluation demonstrated lytic lesions in cranial, femoral, and humorous bones. The skin biopsy verified the diagnosis of LCH. A combination of Vinblastine, VP16, and Dexamethasone regimen was applied for the patient. In the course of the disease, she encountered multiple bilateral pneumothoraxes but didn’t respond to tube thoracostomy and chemotherapy management. The patient died due to respiratory failure raised from complications of lung involvement as a multisystem LCH, 29 days later. Pediatricians should pay much more attention to the cutaneous lesions in the neonatal period especially if there is any risk factor for presenting LCH such as IVF. The lesions should be monitored closely owing to a high correlation between skin lesions and MS LCH.
کلیدواژه‌های انگلیسی مقاله Langerhans cell histiocytosis,In-Vitro Fertilization,Pulmonary involvement,Maculopapular rash,Multisystem LCH
نویسندگان مقاله Saeed Sadr |
Department of Pediatric Pulmonology, Mofid Children's Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Seyedeh Zalfa Modarresi |
Children Growth Disorder Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

Peyman Eshghi |
Pediatric Congenital Hematologic Disorders Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Lobat Shahkar |
Neonatal and Children's Health Research Center, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran

Mitra Khalili |
Department of Radiology, Mofid Children's Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Maliheh Khoddami |
Pediatric Pathology Research Center, Research Institute for Children’s Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Arian Karimi Rouzbahani |
Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran.

نشانی اینترنتی https://www.tanaffosjournal.ir/article_708480_38c5d031910ae6addd78a5df6732fb24.pdf
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