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International journal of Advanced Biological and Biomedical Research، جلد ۱۰، شماره ۱، صفحات ۸۴-۹۷
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| عنوان انگلیسی |
Antidiabetic, Antioxidant and Hypolipidemic potentials of Sterculia Setigera Methanol Stem Bark Extract in Alloxan-Induced Diabetic Rats |
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| چکیده انگلیسی مقاله |
Background: Sterculia setigera is one of the medicinal plants used traditionally to treat various diseases with the insertion of diabetes. Diabetes mellitus is a prolonged metabolic disorder recognized as a hyperglycemia. The present study is aimed at investigating the antidiabetic activity of the methanol stem bark extract of Sterculia setigera.
Methods: LD50 screening was evaluated using standard methods. The sub-chronic effect of Sterculia setigera methanol stem bark extract on body weight, antidiabetic, antioxidant, lipid profile and histopathology were evaluated in Alloxan-induced diabetic rats respectively.
Result: Acute toxicity study of methanol stem bark extract of Sterculia setigera reveal no mortality in the animals at the limit dose of 5000mg/kg during the 14 days observation period. In the invivo study, alloxan was capable of inducing diabetic conditions as there was a significant increase (P<0.05) in the fasting blood glucose (FBG) of the entire induced groups compared to normal control. Groups treated with crude extract of Sterculia setigera (100-400mg/kg) and the standard drug (glibenclamide) showed a significant decrease (P<0.05) in FBg compared to diabetics control. There were significant reductions (P<0.05) in serum TC, TG, VLDL, LDL, CAT, SOD, GPx, Vit E, Vit A, and MDA against diabetic control. On the other hand, significant increments (P<0.05) in body weight and HDL were observed in the treated groups compared to diabetic control diabetic. Histopathological examination showed improvement in the regeneration of pancreatic β-cells islets.
Conclusion: In conclusion, Sterculia setigera stem bark extract exhibit hypoglycaemic, hypolipidemic, and antioxidant effects justifying its ethnomedicinal use for the treatment of diabetes. |
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| کلیدواژه‌های انگلیسی مقاله |
Keywords Antidiabetic,
alloxan,
Sterculia setigera,
hypolipidemic,
Antioxidant,
Glibenclamide |
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| نویسندگان مقاله |
ABDULKARIM ABBA |
KEBBI STATE UNIVERSITY OF SCIENCE AND TECHNOLOGY ALIERO
Ukwuani-Kwaja Angela Nnenna |
BIOCHEMISTYR, FACULTY OF LIFE SCIENCE KEBBI STATE UNIVERSITY OF SCIENCE AND TECHNOLOGY, ALIERO, NIGERIA
JUDE NWAOGU |
BIOCHEMISTRY, LIFE SCIENCES, KEBBI STATE UNIVERSITY OF SCIENCE AND TECHNOLOGY, ALIERO, NIGERIA
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| نشانی اینترنتی |
https://www.ijabbr.com/article_251226_06d182015ceda536ea2588075b18daa6.pdf |
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| زبان مقاله منتشر شده |
en |
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