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Nanomedicine Research Journal، جلد ۶، شماره ۴، صفحات ۳۴۷-۳۵۱
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عنوان انگلیسی Design and evaluation of sesamol loaded hyaluronic acid functionalized phospholipid nanovesicles: DPPH radical scavenging potential assay
چکیده انگلیسی مقاله Objective(s): The unfavorable physicochemical properties of well recognized antioxidant phytoactive sesamol limits its oral bioavailability as well as use as an effective therapeutic agent. Thus present study was started with aim to fabricate sesamol loaded hyaluronic acid anchored phospholipid nanovesicles to minimize limitations associated with conventional delivery of sesamol and to enhance its antioxidant potential.

Methods: Drug encapsulated hyalurosomes were formulated using thin film hydration technique and evaluated with respect to particle size, zeta potential, entrapment efficiency, in vitro release behavior and DPPH radical scavenging assay.

Results: The selected technique was found to be effective for preparation of phospholipid nanovesicles with particle size 200 ± 10.173 nm and zeta potential -29.8 ± 4.16 mV. The drug loaded hyalurosomes revealed significantly better radical scavenging potential compared to free sesamol and unloaded hyalurosomes.

Conclusion: Hyaluronic acid functionalized phospholipid nanovesicles is novel phospholipid based carrier for delivery of phytoactives. Thus formulated phospholipid based system could be promising alternative to deliver sesamol with improved antioxidant potential.
کلیدواژه‌های انگلیسی مقاله Antioxidant phytoactive, Sesamol, Hyalurosomes, DPPH radical scavenging potential
نویسندگان مقاله Manish Kumar Gupta |
School of Pharmaceutical Sciences, Jaipur National University, Jaipur, India- 302017

Vipul A Sansare |
School of Pharmaceutical Sciences, Jaipur National University, Jaipur, India- 302017

Birendra Shrivastava |
School of Pharmaceutical Sciences, Jaipur National University, Jagatpura, Jaipur, Rajasthan-302 017, India

Santosh Jadhav |
Department of Pharmaceutical Chemistry, SVPM's College of Pharmacy, Malegaon, Maharashtra, India- 413115

Prashant Gurav |
Department of pharmaceutics, Indira Institute of pharmacy, Sadavali, Maharashtra

نشانی اینترنتی http://www.nanomedicine-rj.com/article_249482_cea34980017494d5028116f69e7fb996.pdf
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