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Nanomedicine Research Journal، جلد ۶، شماره ۴، صفحات ۳۳۷-۳۴۶
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عنوان انگلیسی Preparation and Characterization of PLGA Encapsulated Tamoxifen Citrate-Magnetite Nanoparticle Via Oil in Water Emulsion Evaporation Technique
چکیده انگلیسی مقاله Current research had successfully encapsulated magnetic nanoparticles (MNP) with selective estrogen receptor drug tamoxifen citrate (TAM) using Poly (d,l-lactice-co-glycolide acid) (PLGA 75:25) via oil in water emulsion technique. TAM is a good example of a drug that is difficult to dissolve. TAM is currently approved for the treatment of hormone-sensitive and early-stage breast cancer as an adjuvant endocrine therapy. The majority of the prescription medicine in today market is made up of poorly soluble, bioavailable, and quickly metabolized and eliminated drug which is a continuously challenges up to these days. Therefore, it is imperative to overcome this disadvantages by encapsulating TAM inside PLGA together with MNP for improved drug delivery. The MNP coated with oleic acid (OA) was synthesized using co-precipitation method and it is known as OAMNP. The fabricated nanohybrid is known as TAM-PLGA-OAMNP where the TAM was encapsulated together with OAMNP within PLGA. XRD results showed that OAMNP is Fe3O4. FTIR spectra revealed that the TAM was successfully encased into the PLGA structure. TAM-PLGA-OAMNP average size is about 131 ± 28 nm as shown in TEM results. The nanohybrid nanoparticles showed the absence of hysteresis loop indicative of superparamagnetic properties.
کلیدواژه‌های انگلیسی مقاله Magnetite nanoparticle, Tamoxifen citrate, Poly (d, l-lactice-co-glycolide acid)
نویسندگان مقاله Emmellie Laura Albert |
Institute of Advanced Technology, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia.

Che Azurahanim Che Abdullah |
Faculty of Science, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.

Ghazaleh Bahmanrokh |
Institute of Advanced Technology, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.

Yuki Shirosaki |
Department of Materials Science, Faculty of Engineering, Kyushu Institute of Technology, 1-1 Sensui-cho, Tobata-ku, Kitakyushu-shi, Fukuoka, 804-8550, Japan

Toshiki Miyazaki |
Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology, 2-4, Hibikino, Wakamatsu-ku, Kitakyushu 808-0196, Japan

Siti Norzulfikaini Yaacob |
Faculty of Science, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.

نشانی اینترنتی http://www.nanomedicine-rj.com/article_249481_76ecccf1a32c08a56fc7932cd3c74e6a.pdf
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