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Iranian Journal of Public Health، جلد ۵۲، شماره ۱۱، صفحات ۲۲۶۰-۲۲۷۱
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عنوان انگلیسی Diagnostic and Prognostic Value of miR-93 in Prostate Cancer: A Meta-Analysis and Bioinformatics Analysis
چکیده انگلیسی مقاله Background: Accurate and non-invasive diagnostic and prognostic markers are necessary to improve patient outcomes. MicroRNAs have been proposed as relatively non-invasive and pertinent biomarkers. miR-93 has been studied for its potential as a diagnostic and prognostic marker in prostate cancer (PCa), but findings from individual studies are inconsistent. We conducted a meta-analysis of its overall differential expression in 13 PCa studies and a bioinformatics analysis to provide a comprehensive appraisal of its diagnostic and prognostic role. Methods: We searched all published papers on miR-93 expression in PCa up to Nov 30, 2022 using PubMed, Science Direct, Web of Science, Cochrane Central Register of Controlled Trials databases. We used RevMan software to Meta-analyze the included literature. A bioinformatics analysis of genes and pathways that might be target to the effect of the mature miR-93-5p was carried out. Results: The pooled standardized mean difference (SMD) of miR-93 expression in PCa, its area under the curve (AUC) and hazard ratio (HR) were 1.26, 95% CI [-0.34–2.86], 0.84, 95% CI [0.76 –0.93] and 1.67, 95% CI [0.98, 2.84] respectively. Bioinformatics analysis revealed that mature miR-93-5p may regulate genes such as SMAD1, SMAD7 and MAPK and the PI3K-Akt signaling pathways. Conclusion: miR-93 has significant diagnostic and prognostic value in PCa. These findings highlight the potential of miR-93 as a non-invasive biomarker for PCa and may contribute to earlier detection and prognostic assessment. The target genes and signaling pathways regulated by miR-93 may provide insights into the underlying molecular mechanisms of PCa.
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نویسندگان مقاله | Hassane Gazzaz
1. Clinical, Metabolic and Molecular Biochemistry Team, Faculty of Medicine and Pharmacy, Mohammed V University,10100 Rabat, Morocco 2. Higher Institute of Nursing Professions and Health Techniques of Marrakech, annex of Safi, Morocco


| Maha El Habchi
Research Laboratory of Psychiatry, Medical Psychology and History of Medicine, Faculty of Medicine and Pharmacy, Mohammed V University, 10100 Rabat, Morocco


| Mohammed El Feniche
Laboratory of Biostatistics, Clinical Research and Epidemiology, Faculty of Medicine and Pharmacy, Mohammed V University, 10100 Rabat, Morocco


| Yassine El Aatik
Research Laboratory of Psychiatry, Medical Psychology and History of Medicine, Faculty of Medicine and Pharmacy, Mohammed V University, 10100 Rabat, Morocco


| Abdelghani El Ouardi
Research Laboratory of Psychiatry, Medical Psychology and History of Medicine, Faculty of Medicine and Pharmacy, Mohammed V University, 10100 Rabat, Morocco


| Ahmed Ameur
Department of Urology, Military Hospital Mohammed V, 10045 Rabat, Morocco


| Abdellah Dami
1. Clinical, Metabolic and Molecular Biochemistry Team, Faculty of Medicine and Pharmacy, Mohammed V University,10100 Rabat, Morocco 2. Department of Biochemistry and Toxicology, Military Hospital Mohammed V, 10045 Rabat, Morocco
نشانی اینترنتی https://ijph.tums.ac.ir/index.php/ijph/article/view/31327
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