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Iranian Journal of Public Health، جلد ۵۲، شماره ۸، صفحات ۱۷۲۰-۱۷۲۹
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عنوان انگلیسی MiR-934 Exacerbates Malignancy of Gastric Cancer Cells by Targeting ZFP36
چکیده انگلیسی مقاله Background: In order to explore new targets for the treatment of gastric cancer (GC), we investigated the regulatory mechanism of miR-934 in the malignant phenotype of gastric cancer. Results: GC tissues and cell lines showed notably higher levels of miR-934. Overexpression of miR-934 promoted cell viability, migration and invasion, while inhibited cell apoptosis of GC cells. ZFP36 was predicted and verified to be the target of miR-934 and low protein levels of ZFP36 were observed in GC tissues. The ZFP36 protein expressions were suppressed by miR-934 overexpression, while were facilitated by miR-934 inhibition. Furthermore, the carcinogenic functions of miR-934 were partially reversed after ZFP36 overexpression. The results of in vivo experiments further demonstrated that miR-934 promoted tumor growth and repressed the protein expression of ZFP36. Conclusion: miR-934 served as a tumor promoter in GC via targeting ZFP36, and ZFP36 overexpression could efficiently relieve malignant phenotypes caused by miR-934, which prompted an exploitable molecular target for GC treatment.
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نویسندگان مقاله | Zhicheng Pan
General Surgery Department, Nanjing Red Cross Hospital, Nanjing City, Jiangsu Province, 210000, China


| Huazhong Yun
General Surgery Department, Nanjing Red Cross Hospital, Nanjing City, Jiangsu Province, 210000, China


| Yun Xiao
General Surgery Department, Nanjing Red Cross Hospital, Nanjing City, Jiangsu Province, 210000, China


| Fei Tong
General Surgery Department, Nanjing Red Cross Hospital, Nanjing City, Jiangsu Province, 210000, China


| Guodong Liu
General Surgery Department, Nanjing Red Cross Hospital, Nanjing City, Jiangsu Province, 210000, China


| Ge Zhang
General Surgery Department, Nanjing Red Cross Hospital, Nanjing City, Jiangsu Province, 210000, China


| Jianbo Han
General Surgery Department, Nanjing Red Cross Hospital, Nanjing City, Jiangsu Province, 210000, China
نشانی اینترنتی https://ijph.tums.ac.ir/index.php/ijph/article/view/30977
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