| چکیده انگلیسی مقاله |
Background: Non-alcoholic fatty liver disease (NAFLD) is the world's most common etiology of chronic liver disease. In this systematic review and meta-analysis, we estimated the prevalence of NAFLD in the Iranian children and adult population.
Methods: A comprehensive search of five international databases, including PubMed, ISI/WOS, ProQuest, Scopus, and Google Scholar, was done from inception to Nov 2022. Studies on NAFLD patients and their risk factors were selected for meta-analysis. The quality of the included studies was assessed by The Joanna Briggs Institute (JBI) Critical Appraisal Checklist for cross-sectional, and cohort studies. The heterogeneity between studies was investigated using Cochran test and I2 statistics. Random and fixed effect models were used for heterogenic and non-heterogenic studies, respectively. We used Comprehensive Meta-Analysis version 3 for conducting meta-analysis.
Results: Twenty studies were finally included. The total prevalence of NAFLD in children, boys, and girls was 6.7% (95% CI: 0.02-0.18), 12.5% (95% CI: 0.04-0.29) and, 10.1% (95% CI: 0.04-0.21), respectively. The total prevalence of NAFLD in obese children, obese boys, and obese girls was 42% (95% CI: 0.18-0.69), 44% (95% CI: 0.13-0.80), and 33 % (95% CI: 0.13-0.62), respectively. The total prevalence of NAFLD in adults was 36.9% (95% CI: 0.31-0.42). The prevalence of NAFLD in men and women was 33.8% (95% CI: 0.27-0.41) and 29.9% (95% CI: 0.21-0.40), respectively.
Conclusion: NAFLD prevalence in Iranian adults and obese children is considerable; however, data about the children population was insufficient. |
| نویسندگان مقاله |
| Soheil Hassanipour
Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran
| Ehsan Amini-Salehi
Student Research Committee, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
| Farahnaz Joukar
1. Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran 2. Caspian Digestive Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran
| Mohammad-Javad Khosousi
Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran
| Farideh Pourtaghi
Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
| Malek Moein Ansar
Department of Biochemistry, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
| Marjan Mahdavi-Roshan
Cardiovascular Diseases Research Center, Department of Cardiology, Heshmat Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
| Forough Heidarzad
Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran
| Golnaz Rashidi-Mojdehi
Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran
| Elham Abdzadeh
Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran
| Azin Vakilpour
School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
| Fariborz Mansour-Ghanaei
1. Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran 2. Caspian Digestive Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran
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