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Iranian Journal of Public Health، جلد ۵۲، شماره ۸، صفحات ۱۵۷۸-۱۵۸۸

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عنوان انگلیسی Case-Control Trials on Risk Factors for Pancreatic Cancer: A Systematic Review and Meta-Analysis
چکیده انگلیسی مقاله Background: The single risk factors of pancreatic cancer (PC) has been extensively studied. We aimed to synthesize results from such studies to identify and estimate multiple independent risk factors of PC. Methods: Articles published up to Feb 28, 2020 in English or Chinese reporting risk factors of PC were reviewed. The fixed-effects model with 95% confidence interval (CI) were used to calculate the pooled Odds Ratio (OR). Data were analyzed using RevMan 5.3. Results: PC was significantly associated with smoking (OR: 1.76, 95% CI: 1.61–1.92, P < 0.00001, I2 = 6%), diabetes (OR: 2.69, 95% CI: 2.52-2.88, P < 0.00001, I2 = 0%), family history of PC (OR: 2.58, 95% CI: 2.13-3.11, P < 0.00001, I2 = 0%), and chronic pancreatitis (OR: 5.84, 95% CI: 3.63-9.41, P < 0.00001, I2 = 0%). Conclusion: Smoking, diabetes, family history of PC, and chronic pancreatitis were independent risk factors for PC. These independent risk factors have an important role in identifying high-risk groups, which is of great significance to reduce the incidence of PC and improve the quality of life and prognosis of patients.  
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نویسندگان مقاله | Yan Yang
School of Economics & Management, Tongji University, Shanghai, China


| Jianwei Shi
School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China


| Jiaoling Huang
School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China


| Mingwang Cheng
School of Economics & Management, Tongji University, Shanghai, China


| Shasha Geng
General Practice Medicine, Dongfang Hospital of Tongji University, Shanghai, China


| Wenya Yu
School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China


| Ning Chen
School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China


| Chen Chen
Shanghai Jing&#x2019;an District Jiangning Road Community Health Service Centre, Shanghai, China


| Zhaoxin Wang
1. Department of Dermatology, The Fifth People&#x2019;s Hospital of Hainan Province, Hainan Medical University, Haikou, China 2. School of Management, Hainan Medical University, Haikou, China



نشانی اینترنتی https://ijph.tums.ac.ir/index.php/ijph/article/view/19057
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