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International Journal of Pediatrics، جلد ۱۱، شماره ۷، صفحات ۱۸۰۴۴-۱۸۰۵۴
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Synbiotic supplementation in type one diabetes mellitus: A Randomized Controlled Clinical Trial |
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| چکیده انگلیسی مقاله |
Background: limited studies have been conducted on the effect of synbiotics supplementation on Type 1 Diabetes Mellitus (T1DM). The current study aimed to evaluate the impacts of synbiotic supplementation on glycemic parameters, lipid profile, and vitamin D levels in children with T1DM.Methods: In this double-blind, randomized controlled trial, 86 T1DM patients aged 4-18 were randomly divided into two equal groups. One group received insulin and a synbiotic supplement once daily for 12 weeks; another group received insulin and a placebo. FBS (fasting blood sugar), HbA1C (hemoglobin A1c), triglycerides, cholesterol, HDL (High-density lipoprotein), LDL (low-density lipoprotein), and vitamin D levels were measured at the beginning and end of the study in both groups.Results: The trend of FBS, HbA1C, triglycerides, cholesterol, HDL, LDL, and vitamin D changes was not significant over time in both groups. Based on the analysis of covariance, the means of FBS and HbA1C were lower in the intervention group (p=0.048 and 0.025, respectively). However, no significant changes in triglycerides, cholesterol, HDL, LDL, and vitamin D levels were observed between the two groups (p= 0.291, 0.291, 0.952, 0.140, and 0.557, respectively).Conclusion: It's suggested that insulin treatment in combination with synbiotic supplementation could improve FBS and HbA1C in T1DM children but had no effects on lipid profile and vitamin D levels. |
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| کلیدواژه‌های انگلیسی مقاله |
Type 1 Diabetes Mellitus,,, ,,Synbiotics,,, ,,Glycemic parameters,,, ,,Lipid profile |
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| نویسندگان مقاله |
| Setila Dalili
Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran.
| Ghazaleh Aldaghi
Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran
| Shahin Koohmanaee
Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran
| Maryam Shahrokhi
Department of clinical pharmacy, Faculty of Pharmacy, Guilan University of Medical Sciences, Rasht, Iran
| Mohammad Esfandiari
1. Student Research Committee, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
2. Student research committee, Virtual School of Medical Education and Management, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
| Seyed Nemati
Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran.
| Jafar Aldaghi
Department of Nutrition, Science and Research Branch, Islamic Azad University, Tehran, Iran.
| Afagh Hassanzadeh Rad
Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran
| Houman Hashemian
Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran
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| نشانی اینترنتی |
https://ijp.mums.ac.ir/article_22773.html |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
original article |
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