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Iranian Journal of Public Health، جلد ۵۲، شماره ۷، صفحات ۱۳۱۱-۱۳۱۹
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عنوان انگلیسی Advances in the Application of Apoptotic Proteins and Alternative Splicing in Tumor Therapy: A Narrative Review
چکیده انگلیسی مقاله An apoptosis-resistant state determined by apoptotic protein expression is commonly seen in the initiation, progression, and treatment failure stages of human cancer, and anti-tumor drugs targeting apoptotic proteins have been increasingly developed over the past three decades. However, the frequently alternative splicing of apoptotic proteins diminished the ability of targeting drugs to bind to apoptotic proteins and, consequently, limit the drug efficacy. Currently, accumulating evidence has demonstrated that many alternative splicing events have been associated to apoptosis resistance in different cancers. Therefore, the intervention targeting alternative splicing for regulating tumor cell apoptosis is expected to become a new strategy and new direction of antitumor therapy. Here, we present well established alternative splicing events that occur in different apoptosis-related genes and their modification by several approaches with cancer therapeutic purposes.  
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نویسندگان مقاله | Jin He
NHC Key Laboratory of Diagnosis and Therapy of Gastrointestinal Tumor, Gansu Provincial Hospital, Lanzhou 730000, China


| Weitao Qiu
Gansu Provincial Maternity and Child-Care Hospital, Lanzhou 730050, China


| Yonghong Li
NHC Key Laboratory of Diagnosis and Therapy of Gastrointestinal Tumor, Gansu Provincial Hospital, Lanzhou 730000, China


| Chaojun Wei
NHC Key Laboratory of Diagnosis and Therapy of Gastrointestinal Tumor, Gansu Provincial Hospital, Lanzhou 730000, China


| Zhongtian Bai
The Second Department of General Surgery, Lanzhou University First Hospital, Lanzhou 730000, China


| Jing Jia
NHC Key Laboratory of Diagnosis and Therapy of Gastrointestinal Tumor, Gansu Provincial Hospital, Lanzhou 730000, China


| Hui Cai
1. NHC Key Laboratory of Diagnosis and Therapy of Gastrointestinal Tumor, Gansu Provincial Hospital, Lanzhou 730000, China 2. Key Laboratory of Molecular Diagnostics and Precision Medicine for Surgical Oncology in Gansu Province, Gansu Provincial Hospital, Lanzhou 730000, China
نشانی اینترنتی https://ijph.tums.ac.ir/index.php/ijph/article/view/30304
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