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International Journal of Pediatrics، جلد ۱۱، شماره ۶، صفحات ۱۷۹۷۹-۱۷۹۸۹
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
The Role of Exosomes in the Pathogenesis of Intrauterine Growth Restriction (IUGR): Future Perspective |
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| چکیده انگلیسی مقاله |
Background: Exosomes are among the factors whose importance has been shown in many diseases today. Recently, it has been shown that exosomes play an important role in the pathogenesis of Intrauterine Growth Restriction (IUGR); however, few studies have been conducted in this regard. Methods: The articles in this review study were retrieved from some databases including PubMed, Google scholar, and Scopus. All the included articles were in English, and those in other languages were excluded. Search keywords included IUGR, exosome, pathogenesis, Mechanism, Cell Signaling, Oxidative Stress, Inflammation, and Endothelial Dysfunction. Results and conclusion: Studies have shown that exosomes contain factors, molecules and gene activators that affect molecular pathways regulation. These molecules play an important role in regulating inflammatory reactions, oxidative stress, and production of Reactive Oxygen Species (ROS). The activation of these pathways can aggravate the clinical symptoms of IUGR. In addition, exosomes can impress induction or inhibition of endothelial dysfunction, which leads to the development of IUGR. Hence, identifying upstream and downstream pathways helps design therapeutic strategies to treat patients. |
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| کلیدواژه‌های انگلیسی مقاله |
Exosome,,, ,,Intrauterine Growth Restriction,,, ,,Pathogenesis,,, ,,Mechanism |
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| نویسندگان مقاله |
| Noushin Modaber
Shahid AkbarAbadi Clinical Research Development Unit (SHACRDU), School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
| Roghayeh Amiri
Shahid AkbarAbadi Clinical Research Development Unit (SHACRDU), School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
| Fatemeh Jayeravand
Shahid AkbarAbadi Clinical Research Development Unit (SHACRDU), School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
| Seyed Amir Hossein Hosseini
Department of Medical Genetics, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
| Bahareh Shateri Amiri Shateri Amiri
Assistant Professor of Internal Medicine Department of Internal Medicine, School of Medicine Hazrat-e Rasool General Hospital Iran University of Medical Sciences.
| Minoo Rostami
Assistant Professor of Internal Medicine Department of Internal Medicine, School of Medicine Hazrat-e Rasool General Hospital Iran University of Medical Sciences.
| Ezzat Khodashenas
Neonatal research center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
| Bahareh Ghahrodizadehabyaneh
Resident of Obstetrics and Gynecology, Medical Faculty, Tehran University of Medical Sciences, Tehran, Iran.
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| نشانی اینترنتی |
https://ijp.mums.ac.ir/article_22582.html |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
review article |
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