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Journal of Chemical and Petroleum Engineering، جلد ۵۷، شماره ۱، صفحات ۹۷-۱۰۹
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
The Influence of Polymer Type and Concentration on the Metoprolol Mass Transfer in Extended-Release Tablet of Metoprolol Succinate |
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| چکیده انگلیسی مقاله |
Metoprolol has been widely used for controlling high blood pressure, preventing myocardial reinfarction, setting rate changes, setting heart rhythm, treatment of chronic angina and preventing excessive bleeding during surgery. The purpose of this research is formulation and manufacture of extended release tablets of metoprolol succinate that conform to all the in vitro physicochemical US Pharmacopoeia national formulary (USP32). For preparing the tablets, the hydrophilic HPMC(K100M) polymer was used in direct compression method. Release of metoprolol in phosphate buffer having pH=6.8 (USP32) was measured by HPLC. Also, using experimental correlation of diffusivity in buffer medium and Gurney-Lurie charts during tablet enlargement with time, diffusion coefficients of drug and partition coefficients were obtained at different time steps. The rate of drug release depends on the type, viscosity and polymer concentration. Drug release results over 20 hours for polymers of HPMC(K100M), HPMC(K4M), HPMC(K15M), polyethylene oxide, ethyl cellulose, Eudragit (RL100) were investigated and compared. The results demonstrated that HPMC(K100M) met the standards of USP32 very well and was superior over the other polymers tested. |
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| کلیدواژه‌های انگلیسی مقاله |
Metoprolol,Extended-release tablets,HPMC polymer,Mass Transfer |
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| نویسندگان مقاله |
Parissa Khadivparsi |
School of Chemical Engineering, College of Engineering, University of Tehran, Tehran, Iran
Morteza Rafiee-Tehrani |
Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran,
Iran
Farid Dorkoosh |
Medical Biomaterial Research Center, Tehran University of Medical Sciences, Tehran, Iran
Jabber Babaee Darabad |
Shimi Pajohan Sabze Nikan, Tehran, Iran
Hedayat Azizpour |
School of Chemical Engineering, College of Engineering, University of Tehran, Tehran, Iran
Nariman Rezamandi |
Department of Civil, Chemical, Environmental, and Material Engineering (DICAM), Alma Mater
Studiorum – University of Bologna, Bologna, Italy
Nadia Larki |
School of Chemical Engineering, College of Engineering, University of Tehran, Tehran, Iran
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| نشانی اینترنتی |
https://jchpe.ut.ac.ir/article_91148_491d58e20c64c3802d71820f66e31c4f.pdf |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
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