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Iranian Journal of Kidney Diseases، جلد ۱۰، شماره ۶، صفحات ۳۵۸-۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| عنوان انگلیسی |
Effects of Angiotensin II Receptor Blockade on Soluble Klotho and Oxidative Stress in Calcineurin Inhibitor Nephrotoxicity in Rats |
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| چکیده انگلیسی مقاله |
Introduction. Calcineurin inhibitor nephrotoxicity is major problem after organ transplantation. It is multifactorial, but oxidative stress may have an important role in this process. It has been shown that angiotensin II receptor blockers have renoprotective effects but their molecular mechanism is largely unknown. Antioxidative effect is an important role of the recently known anti-aging protein, klotho. This study aimed to evaluate effect of valsartan in alleviation of cyclosporine A nephrotoxicity via a probable increase in serum klotho levels or decreasing oxidative stress. Materials and Methods. Thirty-two Sprague-Dawley rats were divided into 4 groups to receive 1 mL/kg/d of olive oil as control; 30 mg/kg/d of cyclosporine; 30 mg/kg/d of cyclosporine and 50 mg/kg/d of valsartan; and 50 mg/kg/d of valsartan. After the 6 weeks of administration period, serum levels of klotho and 8-hydroxydeoxyguanosine were measured using an enzyme-linked immunosorbent assay. Serum malondialdehyde level was measured spectrophotometrically. Results. The mean serum level of klotho was significantly lower in the cyclosporine group compared with control and valsartan groups. Klotho level in the valsartan group was significantly higher than those in the other groups. The cyclosporine group was detected to have significantly higher serum 8-hydroxydeoxyguanosine and malondialdehyde levels compared with the other study groups. The levels of klotho were negatively correlated with 8-hydroxydeoxyguanosine and malondialdehyde levels. Conclusions. Administration of valsartan may lead to attenuation of the nephrotoxic side effect of cyclosporine via enhancing klotho and decreasing oxidative stress levels. |
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| نویسندگان مقاله |
سینا رییسی | sina raeisi
امیر قربانی فرزامی jo | amir ghorbani hagh jo
حسن ارگانی | hasan argani
سیاوش dastmal chi | siavoush dastmal chi
باب الله قاسمی | babollah ghasemi
تیمور قاضی زاده | teymour ghazi zadeh
نادره رشت chi زاده | nadereh rasht chi zadeh
محبوب نعمتی | mahboub nemati
مهران mes گری عباسی | mehran mes gari abasi
نسرین بارگاهی | nasrin bargahi
علی مطاع | ali mota
امیر منصور وطن خواه | amir mansour vatan khah
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| نشانی اینترنتی |
http://www.ijkd.org/index.php/ijkd/article/view/2730 |
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| زبان مقاله منتشر شده |
en |
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