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Iranian Journal of Public Health، جلد ۵۲، شماره ۵، صفحات ۹۰۳-۹۱۲
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عنوان انگلیسی Application Value of PCSK9 Inhibitor in Cardiovascular High Risk Patients: A Meta-Analysis
چکیده انگلیسی مقاله Background: Proprotein convertase subtilisin / Kexin type 9 (PCSK9) inhibitors are efficacious lipid-lowering agents. This drug is related to improving the prognosis of patients with cardiovascular disease (CVD). The purpose of this meta-analysis was to systematically analyze the safety and efficacy of PCSK9 inhibitors in all published randomized controlled trials (RCTs). Methods: As of October 25, 2021, we searched PubMed, EMBASE, MEDLINE, Cochrane Library and web of science. Results: From 684 articles, we included 11 trials for meta-analysis, including 52511 participants (26938 in the PCSK9 inhibitor group and 25573 in the control group). In terms of effectiveness, PCSK9 inhibitors reduced the risk of major adverse cardiovascular events(MACE) (OR=0.89, 95% Cl: 0.83-0.95, P=0.0009), but did not significantly reduce the risk of cardiovascular death (OR=0.95, 95% Cl: 0.84-1.07, P=0.38) or all-cause death (OR=0.93, 95% Cl: 0.85-1.03, P=0.18); In terms of safety, PCSK9 did not increase the risk of treatment-emergent adverse events (TEAE)(OR=0.98, 95% Cl: 0.94-1.02, P=0.28). Conclusion: PCSK9 inhibitors can significantly reduce the risk of MACE in patients with high cardiovascular risk, which is well tolerated, but the impact on the risk of death is unclear.  
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نویسندگان مقاله | Liming Zhao
Department of Vascular Surgery, Liu Zhou People’s Hospital, Guangxi, 545006, China


| Ying Liu
Department of Endocrinology, Affiliated Hospital of Youjiang Medical University for Nationalities, Guangxi, China


| Ziting Cao
Department of Vascular Surgery, Liu Zhou People’s Hospital, Guangxi, 545006, China


| Jun Wang
Department of Vascular Surgery, Liu Zhou People’s Hospital, Guangxi, 545006, China


| Xin Huo
Department of Vascular Surgery, Liu Zhou People’s Hospital, Guangxi, 545006, China
نشانی اینترنتی https://ijph.tums.ac.ir/index.php/ijph/article/view/30305
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