| چکیده انگلیسی مقاله |
Background: There is a paucity of RCTs that have systemically evaluated the effects of L.GG on the prevention of NEC and LOS in preterm neonates.To study different incidence rates of NEC and LOS. Secondary outcomes were the incidence of hyperbillirubinaemia, mortality, side effects and weight gain.Methods: This is an open labeled RCT. Preterm infants with a gestational age of < 35 weeks were assigned to three groups: A(L.GG sachet 6 billion organism), B(L.GG drops 2 billion organisms), C (no probiotic) using fixed block randomization. Probiotic was administered till the neonate reached the corrected gestational age of 36 weeks or a maximum of 4 weeks.Results: Of 123 neonates, NEC developed in 2(4.88%) in group A versus 1(2.38%) in group B and 0 (0%) in group C (p value- 0.37). LOS also developed in 5(12.2%) in group A versus 3(7.14%) in group B and 3(7.5%) in group C (p-value 0.7). Moreover, 92.68% of subjects were successfully discharged in group A, 95.24% in group B and 90% in group C ( p-value 0.55). A significant difference was found between the incidence of hyperbilirubinemia (21.95% in group A versus 47.5% in group C (p-value 0.02) and 28.92% in Group A+B versus 47.5% in group C (p-value 0.04). There was a significant difference in weight gain at 1 month of age; 9.65±3.72 grams/kg/day in group A versus 6.58±3.86 grams/kg/day in group C (p-value 0.002) and 8.98±4.49 grams/kg/day in group B versus 6.58±3.86 grams/kg/day in group C (p-value 0.03).Conclusion: L.GG alone as a single strain administered in both high and low dosages has no significant effect on reducing the incidence of NEC, LOS and yielding immediate outcomes. A larger sample size and a blinded study are required to draw more accurate conclusions. |
| نویسندگان مقاله |
| Manish Rasania
Department of Paediatrics, Smt. B.K.Shah Medical Institute & Research Center, Sumandeep Vidhyapeeth (deemed to be University), Waghodia taluka, Vadodara District, India
| Guntupalli Shravya
Department of Paediatrics, Smt. B.K.Shah Medical Institute & Research Center, Sumandeep Vidhyapeeth (deemed to be University), Waghodia taluka, Vadodara District, India
| Pooja Patel
Department of Paediatrics, Smt. B.K.Shah Medical Institute & Research Center, Sumandeep Vidhyapeeth (deemed to be University), Waghodia taluka, Vadodara District, India
| Dipika Bhil
Department of Paediatrics, Smt. B.K.Shah Medical Institute & Research Center, Sumandeep Vidhyapeeth (deemed to be University), Waghodia taluka, Vadodara District, India
| Sunil Pathak
Department of Paediatrics, Smt. B.K.Shah Medical Institute & Research Center, Sumandeep Vidhyapeeth (deemed to be University), Waghodia taluka, Vadodara District, India
| Sruchi Bhargava
Department of Paediatrics, Smt. B.K.Shah Medical Institute & Research Center, Sumandeep Vidhyapeeth (deemed to be University), Waghodia taluka, Vadodara District, India
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