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Iranian Journal of Diabetes and Obesity، جلد ۱۵، شماره ۱، صفحات ۷-۱۳
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عنوان انگلیسی Effect of Vitamin C Therapy on Serum Parameters in Patients with Type 2 Diabetes Mellitus: Clinical Trial
چکیده انگلیسی مقاله Objective: Diabetes mellitus (DM) is a leading cause of morbidity and death worldwide. DM will affect 570.9 million people worldwide by 2025. The usefulness of vitamin C in improving diabetes control has been a point of contention. Materials and Methods: This clinical-trial double-blind study with control groups was conducted on 164 patients with type 2 diabetes mellitus (T2DM). The intervention group received 1000 mg of oral vitamin C daily, and a placebo was administered to the controls. To analyze the obtained data, one-way ANOVA was used in SPSS software (version 20). A P< 0.05 was considered statistically significant. Results: Fasting blood sugar (FBS), hemoglobin A1c (HbA1C), triglyceride (TG), and high-density lipoprotein (HDL) were improved significantly in the intervention group (P< 0.05), while the low-density lipoprotein (LDL) and cholesterol were unaffected (P> 0.05). HbA1C and LDL levels in the control group increased significantly (P< 0.05). Meanwhile, this group's HDL levels decreased considerably. Conclusion: Our findings support the consumption of vitamin C to complement the primary treatment for DM. According to our results, vitamin C provides a clear benefit over a placebo in the treatment of diabetic patients' serum parameters.  
کلیدواژه‌های انگلیسی مقاله Clinical trial, Diabetes mellitus, Blood glucose, HbA1C, HDL, LDL, Ascorbic acid
نویسندگان مقاله | Shiva Kordestani
Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.


| Seyyed Behzad Razavi
Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.


| Mona Najaf Najafi
Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.


| Parvin Layegh
Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.


| Mohammadmobin Miri Moghaddam
Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.


| Amirali Aali
Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.


| Masoud Mohebbi
Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
نشانی اینترنتی http://ijdo.ssu.ac.ir/browse.php?a_code=A-10-30-367&slc_lang=en&sid=1
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