این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Asia Pacific Journal of Medical Toxicology، جلد ۱۱، شماره ۴، صفحات ۱۲۸-۱۴۵
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Serum Total Antioxidant Status and Oxidative Stress Marker Levels of Subjects in a Lead-Zinc Mining Community of Ebonyi State, Nigeria: Evidence of Lead Intoxication
چکیده انگلیسی مقاله Background: This study intended to investigate blood lead and serum total antioxidant capacity and oxidative stress marker levels of subjects in a lead-zinc mining community of Ebonyi State, Nigeria.Methods: Sixty-eight (68) occupationally-exposed (OE) and 62 environmentally-exposed (EE) to lead in Enyigba community and 70 non-inhabitants (controls), were recruited for this study. Blood samples were collected from them for blood lead (BL), malondialdehyde (MDA), total antioxidant capacity (TAC), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPX), assays using standard methods. Data were analyzed with the IBM SPSS software and means were compared using One Way ANOVA and t-test. Statistical differences was considered significant at p< 0.05.Result: Mean BL significantly rose in the OE and EE groups (p< 0.0001 respectively) than the controls. TAC decreased significantly in the OE (p< 0.01), but increased in EE (p< 0.05) compared with the control groups, while SOD, CAT, and MDA decreased significantly in the OE (p< 0.01 respectively) and EE (p< 0.01 each) versus control group. Significant higher TAC and lower CAT were recorded in the EE compared with the OE (p< 0.05) subjects. GPx significantly increased (p< 0.05) in the OE compared with the control group. Only CAT correlated significantly with lead in the EE subjects. BL, MDA, and CAT differed significantly (< 0.0001 respectively), and SOD (< 0.05) varied with age. Children < 10 years recorded the highest BL concentration (34.77±12.46) b young adults aged 21-30 the lowest, which was significantly lower than in the other age categories.Conclusion: The elevated MDA concentration and reduced antioxidant activities indicated some oxidative stress damage resulting from lead toxicity.
کلیدواژه‌های انگلیسی مقاله Blood lead, Antioxidants, Oxidative stress, occupationally-exposed, environmentally-exposed, intoxication
نویسندگان مقاله | Aniema Ituen
Department of Physiology, Faculty of Basic Medical Sciences, College of Medicine, University of Nigeria, Nsukka.


| Nkoyo Nubila
Department of Pharmacology and Therapeutics, Faculty of Medical Sciences, College of Medicine, University of Nigeria, Nsukka.


| Fre Otuu
Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka.


| Irene Shuneba
Department of Medicine, Faculty of Basic Medical Sciences, College of Medicine, University of Nigeria, Nsukka


| Amechi Katchy
Department of Anatomy, Faculty of Basic Medical Sciences, College of Medicine, University of Nigeria, Nsukka


| Bond Anyaehie
Department of Physiology, Faculty of Basic Medical Sciences, College of Medicine, University of Nigeria, Nsukka


| Elvis Shu
4. Dept. of Pharmacology and Therapeutics, College of Medicine, University of Nigeria, Nsukka, Nigeria
نشانی اینترنتی https://apjmt.mums.ac.ir/article_21780.html
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Article
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات