Infection Epidemiology and Microbiology، جلد ۹، شماره ۱، صفحات ۰-۰
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عنوان انگلیسی Investigation of Metallobetalactamase (blaIMP & blaVIM) and Carbapenemase (blaKPC & blaGES) Genes in Gram Negative Rods Isolated from Cancer Patients
چکیده انگلیسی مقاله Aims: Bacterial infections are the most common complication in cancer patients. Infection with multi-drug resistant bacteria has recently become a worrying phenomenon in cancer patients. This study focused on Gram-negative bacteria isolated from clinical samples of cancer patients. The purpose of this study was to evaluate the presence and prevalence of drug resistance genes, including metallobetalactamase (blaIMP and blaVIM) and carbapenemase (blaKPC and blaGES) genes, in the main bacteria agents of nosocomial infections in cancer patients, such as Acinetobacter baumannii, Pseudomonas aeruginosa, Klebsiella pneumoniae, and Escherichia coli. Materials & Methods: Common biochemical methods were used to identify bacterial isolates. Antimicrobial susceptibility testing was performed according to the standard method recommended by the Clinical and Laboratory Standards Institute (2019). Polymerase chain reaction(PCR) method was also used to check the presence and prevalence of resistance genes. Findings: During six months, from May to November 2020, 250 clinical samples were collected from cancer patients in Ayatollah Khansari hospital in Arak city, Iran. From which 80 Gram-negative bacilli were isolated, including 33 (41.2%) E. coli, 15 (18.7%) A. baumannii complex, 12 (15%) P. aeruginosa, eight (10%) K. pneumoniae, seven (8.7%) Citrobacter freundii, and five (6.2%) Enterobacter aerogenes isolates. The frequency of blaKPC, blaGES, blaIMP, and blaVIM genes was 39.95, 21.25, 16.25, and 17.45%, respectively. Conclusion: The present study emphasizes the importance of identifying gram negative rods and their resistance genes (metallobetalactamase and carbapenemase genes) from cancer patients, and carrying out preventive instructions
کلیدواژه‌های انگلیسی مقاله Infections, Gram-negative bacteria, Carbapenemase, Drug resistance, Cancer patients
نویسندگان مقاله | Fahime Maleki
Department of Immunology & Microbiology, Arak University of Medical Sciences, Arak, Iran


| majid akbari
Infectious Research Center, Arak University of Medical Sciences, Arak, Iran


| Mohammadmohmmad Arjomandzadegan
Infectious Research Center, Arak University of Medical Sciences, Arak, Iran


| azam Ahmadi
Infectious Research Center, Arak University of Medical Sciences, Arak, Iran
نشانی اینترنتی http://iem.modares.ac.ir/browse.php?a_code=A-10-11808-4&slc_lang=en&sid=4
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