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Avicenna Journal of Phytomedicine، جلد ۱۳، شماره ۲، صفحات ۱۵۳-۱۶۴
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عنوان انگلیسی The effect of curcumin-piperine on cardiometabolic, inflammatory and oxidative stress factors and macular vascular density in optical coherence tomography angiography (OCTA) in patients with non-proliferative diabetic retinopathy: Study protocol for a randomized, double-blind controlled trial
چکیده انگلیسی مقاله Objective: Curcumin is a safe phytochemical with antioxidant, anti-inflammatory, antidiabetic, and lipid-lowering effects. This study aims to investigate the efficacy of curcumin-piperine in non-proliferative diabetic retinopathy.Materials and Methods: In this double-blind randomized trial, 60 diabetic retinopathy patients after meeting the inclusion criteria will be randomly assigned to two groups of curcumin-piperine supplementation (1000 mg per day for 12 weeks) or receiving placebo. The density of small blood vessels in the retina by optical coherence tomography angiography (OCTA), fasting blood glucose, triglyceride, renal indices (blood urea nitrogen and creatinine), high-sensitivity C-reactive protein, total antioxidant capacity, total oxidant status, body mass index, waist circumference, and weight will be measured.Conclusion: If the beneficial effects of curcumin on diabetic retinopathy are observed, this safe, this natural and inexpensive herbal supplement can be considered a therapeutic solution in these patients.
کلیدواژه‌های انگلیسی مقاله Diabetes Mellitus, Curcumin, Piperine, Diabetic retinopathy, OCTA
نویسندگان مقاله | Sepide Amini
Nutrition and Food Security Research Center, Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran


| Amirhossein Sahebkar
Department of Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran


| Alireza Dehghani
Ophthalmology Ward, Feiz Hospital, Isfahan University of Medical Sciences, Isfahan, Iran


| Bijan Iraj
Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran


| Abdolreza Rezaeian-Ramsheh
Ophthalmology Ward, Feiz Hospital, Isfahan University of Medical Sciences, Isfahan, Iran


| Gholamreza Askari
Nutrition and Food Security Research Center, Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran


| Muhammed Majeed
Sabinsa Corporation, East Windsor, NJ, United States


| Mohammad Bagherniya
Nutrition and Food Security Research Center, Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
نشانی اینترنتی https://ajp.mums.ac.ir/article_21512.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Research Article
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