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Journal of Nanostructures، جلد ۱۰، شماره ۳، صفحات ۵۰۹-۵۱۷
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عنوان انگلیسی Evaluation of Biological Activity of 5-Fluoro-Isatin Thiosemicarbazone Derivatives
چکیده انگلیسی مقاله Isatin based materials can exhibit a wide range of biological activities including antimicrobial, antiviral, antifungal, anthelmintic, antitumor, anti-HIV, anti-inflammatory, antidepressant, antioxidant, anticonvulsant, antitubercular, analgesic, and central nervous system depressant activities. In this study, four compounds containing 5-Fluoro-isatin thiosemicarbazone with methoxyphenyl or methoxyphenyl in different positions and zinc complexes were evaluated based on their biological activities. Compound 2 was the strongest compound affecting gram-negative bacteria compared to the other compounds. Also, this compound indicated better antimicrobial activity than positive control antibiotics. Besides, compound 3 was the only compound that inhibited the growth of Salmonella spp. such as Salmonella enteritidis ATCC 13076 and Salmonella typhimurium NRRLE 4463. 5-Fluoro-Isatin thiosemicarbazone and its derivatives also showed DNA protection property from moderate to good protections. Among them, compound 4 displayed the highest DNA binding affinity. These compounds possessed a capacity for utilization as drugs or drug additives based on their effects on bacteria strains and DNA binding affinity.
کلیدواژه‌های انگلیسی مقاله 5-Fluoro-Isatin, Antimicrobial activity, DNA protection, Thiosemicarbazone
نویسندگان مقاله Mohamed Abdulhamid Ganim Ramadan |
Department of Genetics and Bioengineering, Faculty of Engineering and Architecture, Kastamonu University

Mehmet Cengiz Baloglu |
Department of Genetics and Bioengineering, Faculty of Engineering and Architecture, Kastamonu University

Yasemin Celik Altunoglu |
Department of Genetics and Bioengineering, Faculty of Engineering and Architecture, Kastamonu University

Fatma Kandemirli |
Department of Biomedical Engineering, Faculty of Engineering and Architecture, Kastamonu University

Hakan Burhan |
en Research Group, Department of Biochemistry, Faculty of Arts and Science, Dumlupınar University, Evliya Çelebi Campus, 43100 Kütahya, Turkey

Ayşenur Aygün |
en Research Group, Department of Biochemistry, Faculty of Arts and Science, Dumlupınar University, Evliya Çelebi Campus, 43100 Kütahya, Turkey

Hakan Sayiner |
Department of Infectious Diseases, Faculty of Medicine, Adiyaman University, Adiyaman, Turkey

Filiz Ozyigit |
Department of Medical Sciences, Faculty of Medicine, Kutahya University of Health Sciences

Fatih Sen |
Sen Research Group, Department of Biochemistry, Faculty of Arts and Science, Dumlupınar University, Evliya Çelebi Campus, 43100 Kütahya, Turkey

نشانی اینترنتی https://jns.kashanu.ac.ir/article_110794_98d169c900657895924ba535d1680a4f.pdf
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