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Journal of Nanostructures، جلد ۱۲، شماره ۳، صفحات ۵۴۶-۵۵۶
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عنوان انگلیسی Enhancing the Antibacterial and Anticancer Activity of Ciprofloxacin by Encapsulating into Shellac-Chitosan Nano Particles (CNPs)
چکیده انگلیسی مقاله This study demonstrates a preparation of a nanocarrier for drug delivery system which based on combining two natural materials shellac (SH) and chitosan (CH). The chitosan shellac NPs (SH-CH NPs) was loaded with ciprofloxacin drug to enhance its anticancer and antibacterial activity. The shellac – chitosan NPs (SH-CH NPs) size was measured using DLS and its size was58.8nm ± 3.4, while the morphology of the nano compound was identified using FESEM, TEM techniques. We diagnosed SH-CH NP synthesis by FTIR, HNMR and DSC techniques. The results of MTT test showed a high inhibition rate of 55.45% for A375 melanoma cells, and a low inhibition rate for normal cells (HFF) range (8.51%-32.93%)when incubated with Cipro-SH-CH NPs. Also, the results reinforced the possibility of using ciprofloxacin loaded on chitosan – shellac NPs as a promising nanocarrier with low cytotoxicity, and high activity as an antibacterial with a diameter of 40 mm with both type of positively and negatively charged bacteria.
کلیدواژه‌های انگلیسی مقاله Ciprofloxacin, Chitosan, Drug delivery system, shellac
نویسندگان مقاله Sulaf Hussein Ali |
Department of Chemistry, College of Science, University of Babylon, Hilla 51001, Iraq

Saba S. M. Al-Obaidy |
Department of Chemistry, College of Science, University of Babylon, Hilla 51001, Iraq

Faris Hamood Mohammed |
Department of Chemistry, College of Science, University of Babylon, Hilla 51001, Iraq

نشانی اینترنتی https://jns.kashanu.ac.ir/article_112040_ae3e7ece8dc9b6676c785f2fe4fc17c5.pdf
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