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Journal of Medicinal Plants and By-products، جلد ۱۰، شماره Special، صفحات ۵۱-۵۹
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عنوان انگلیسی Evaluation of the Anti-inflammatory and Cytotoxic Activity of Methanol Extracts of Psacalium decompositum and Scopulophyla parryi in VERO and Detroit Cell Lines
چکیده انگلیسی مقاله Periodontal diseases are characterized by inflammation and destruction of tooth-supporting tissues. There is interest in anti-inflammatory substances of plant origin because of their advantage in relation to classic anti-inflammatory drugs. The cytotoxic and anti-inflammatory effect of extracts of Scopulophila parryi and Psacalium decompositum (A.Gray) H.Rob. & Brettell were evaluated with the 3-[4,5-dimethylthiazole-2-yl]-2,5-diphenyltetrazolium (MTT) method and their pro-inflammatory cytokine profile was determined in a human peripheral blood monocyte culture model. The plant was collected and identified and the methanol extract was prepared by maceration. Cytotoxicity was evaluated in vitro with the MTT (3-[4,5-dimethylthiazole-2-yl]-2,5-diphenyltetrazolium) assay in two cell lines, VERO and Detroit 551 human fibroblasts. The anti-inflammatory activity of human peripheral blood monocytes and gene expression of the proinflammatory cytokines, IL-1, IL-6 and IL-8, were evaluated The extract of P. decompositum was less toxic on the VERO and Detroit 551 cell lines with a DL50 of 77.30 μg/mL and the S. parryi extract had 150.58 μg/mL. Both extracts significantly reduced expression of IL-1β, IL-6, and IL-8 at 300 μg/mL for S. parryi and at 400 μg/mL for P. decompositum. The extract of P. decompositum was less toxic for both cell lines and the two methanol extracts are good alternatives as immunomodulators of proinflammatory cytokines.
کلیدواژه‌های انگلیسی مقاله Cytokines, Toxicity, cell lines, periodontal
نویسندگان مقاله Patricia Garcia-Palencia |
School of Biological Sciencies, Universidad Autonoma de Nuevo Leon, Pedro de Alba s/n, Ciudad Universitaria San Nicolas de Los Garza, Mexico

Catalina Rivas-Morales |
School of Biological Sciencies, Universidad Autonoma de Nuevo Leon, Pedro de Alba s/n, Ciudad Universitaria San Nicolas de Los Garza, Mexico

Azucena Oranday-Cardenas |
School of Biological Sciencies, Universidad Autonoma de Nuevo Leon, Pedro de Alba s/n, Ciudad Universitaria San Nicolas de Los Garza, Mexico

Myriam De La Garza-Ramos |
School of Dentistry,“Dr. Jose Eleuterio Gonzalez” University Hospital, Universidad Autonoma de Nuevo Leon, Monterrey, Mexico

Catalina Leos-Rivas |
School of Biological Sciencies, Universidad Autonoma de Nuevo Leon, Pedro de Alba s/n, Ciudad Universitaria San Nicolas de Los Garza, Mexico

Ernesto Torres López |
School of Medicine,“Dr. Jose Eleuterio Gonzalez” University Hospital, Universidad Autonoma de Nuevo Leon, Monterrey, Mexico

نشانی اینترنتی https://jmpb.areeo.ac.ir/article_122340_7acb754ce55efa6ae2343bf0c87b7a40.pdf
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