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Iranian Journal of Basic Medical Sciences، جلد ۲۵، شماره ۹، صفحات ۱۰۴۲-۱۰۴۴
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عنوان انگلیسی Wound dressings incorporating microRNAs: Innovative therapy for diabetic wound treatment
چکیده انگلیسی مقاله Diabetic wounds are the most critical complication in patients with diabetes, which often lead to hospitalization and limb amputations. Diabetic foot ulcers (DFU) is characterized by infections, prolonged inflammation, and a delayed wound healing process. Different types of medical procedures including surgical therapy, drug delivery, stem cell therapy, and wound dressings are used to manage DFU. Bioactive dressings such as hydrogels, nanofiber, and collagens are promising materials that can accelerate the healing process. The wound dressing materials can also be loaded with bioactive molecules like nucleic acids. MicroRNAs (miRNAs) are small non-coding RNA molecules that have recently emerged as regulators of impaired wound healing and could be a target for DFU treatment. miRNA therapeutics can be delivered to the wound region using different delivery systems such as exosomes and nanoparticles. These wound dressings have a high potential for treating diabetic wounds by topical delivery of certain miRNAs in a sustained release manner.
کلیدواژه‌های انگلیسی مقاله Diabetic foot, Dressings, MicroRNA, Wound healing, Wound therapy
نویسندگان مقاله | Mohammad Hasan Soheilifar
Department of Medical Laser, Medical Laser Research Center, Yara Institute, ACECR, Tehran, Iran


| Nastaran Masoudi-Khoram
Department of Biophysics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran
نشانی اینترنتی https://ijbms.mums.ac.ir/article_20927.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Letter to the Editor
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