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Avicenna Journal of Phytomedicine، جلد ۱۲، شماره ۶، صفحات ۶۰۲-۶۱۳
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چکیده فارسی مقاله
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عنوان انگلیسی Effect of sesamol on damaged peripheral nerves: Evaluation of functional, histological, molecular, and oxidative stress parameters
چکیده انگلیسی مقاله Objective: Peripheral nerve injury is a clinical problem that may cause sensory and motor inabilities. Sesamol is an antioxidant that can help in repairing damaged central nervous system (CNS) and other organs. The present study aimed to investigate whether the antioxidant effects of sesamol could improve the function, structure, and myelination in rats’ damaged peripheral nervous system (PNS).Materials and Methods: In this study, 28 adult male Wistar rats were randomly divided into four groups. In the sham group, the sciatic nerve was exposed and restored to its place without inducing crush injury. The control received DMSO (solvent) and the two experimental groups received 50 or 100 mg/kg sesamol intraperitoneally for 28 days after sciatic nerve crush injury, respectively. Next, sciatic function index (SFI), superoxide dismutase (SOD) activity, malondialdehyde (MDA) level, expression of nerve growth factor (NGF) and myelin protein zero (MPZ) proteins in the sciatic nerve, and histological indices of the sciatic nerve and gastrocnemius muscle were evaluated. Results: The results showed that sesamol reduced oxidative stress parameters, increased expression of NGF and MPZ proteins, and improved function and regeneration of the damaged sciatic nerve. Furthermore, a significant regeneration was observed in the gastrocnemius muscle after treatment with sesamol. Although administration of both doses of sesamol was useful, the 100 mg/kg dose was more effective than the 50 mg/kg one.Conclusion: The results suggest that sesamol may be effective in improving damaged peripheral nerves in rats by reducing oxidative stress and increasing the expression of NGF and MPZ proteins.
کلیدواژه‌های انگلیسی مقاله Nerve growth factor, MPZ protein, Oxidative stress, Peripheral nerve injuries, Regeneration, Sesamol
نویسندگان مقاله | Nastaran Amerian
Nervous System Stem Cells Research Center, Semnan University of Medical Sciences, Semnan, Iran


| Athar Talebi
Nervous System Stem Cells Research Center, Semnan University of Medical Sciences, Semnan, Iran


| Manouchehr Safari
Nervous System Stem Cells Research Center, Semnan University of Medical Sciences, Semnan, Iran


| Hamid Reza Sameni
Nervous System Stem Cells Research Center, Semnan University of Medical Sciences, Semnan, Iran


| Ali Ghanbari
Research Center of Physiology, Semnan University of Medical Sciences, Semnan, Iran


| Parisa Hayat
Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran


| Moslem Mohammadi
Department of Physiology, Molecular and Cell Biology Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran


| Maryam Ardekanian
Department of Biotechnology, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran


| Sam Zarbakhsh
Nervous System Stem Cells Research Center, Semnan University of Medical Sciences, Semnan, Iran
نشانی اینترنتی https://ajp.mums.ac.ir/article_20663.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Research Article
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