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Avicenna Journal of Phytomedicine، جلد ۱۲، شماره ۶، صفحات ۵۸۹-۶۰۱
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عنوان انگلیسی Evaluation of the effect of crocin on prevention of atrial fibrillation after coronary artery bypass grafting or heart valve replacement: A double-blind, randomized, placebo-controlled trial
چکیده انگلیسی مقاله Objective: The aim of this study was to evaluate the effect of crocin on the prevention of atrial fibrillation after coronary artery bypass grafting (CABG) and heart valve replacement.Materials and Methods: 100 patients who were scheduled for CABG or heart valve replacement surgeries were randomly assigned into two groups of treatment and placebo. In the treatment group, patients received crocin tablets from three days prior to surgery and on the first three postoperative days (for a total of six days). During the first three days after surgery, postoperative atrial fibrillation (POAF) was assessed by electrocardiogram monitoring. Prooxidant–antioxidant balance (PAB) and c-reactive protein (CRP) levels were also assessed.Results: POAF developed in 7 patients in the treatment group versus 18 patients in the control (p=0.02). PAB levels were significantly lower in the crocin group (p< 0.001), while differences in CRP levels were insignificant (p=0.39).Conclusion: It seems that prophylactic use of crocin is effective in reducing the incidence of POAF in patients undergoing heart surgeries.
کلیدواژه‌های انگلیسی مقاله Atrial fibrillation, Coronary artery bypass graft, Heart valve replacement, Crocin
نویسندگان مقاله | Seyyed Hamed Hashemi Shahri
Department of Clinical pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran


| Ghasem Soltani
Department of Anesthesia, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran


| Mohammad Abbasi Teshnizi
Cardiac Surgeon, Department of Cardiac Surgery, Mashhad University of Medical Sciences, Mashhad, Iran


| Aliasghar Moeinipour
Cardiac Surgeon, Department of Cardiac Surgery, Mashhad University of Medical Sciences, Mashhad, Iran


| Mohammad Tayyebi
Vascular and Endovascular Surgery Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran


| Reza Javidi Dasht Bayaz
Cardiovascular Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran


| Farshad Abedi
Department of Clinical pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran


| Vahid Ghavami
Department of Biostatistics, Social Determinants of Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran


| Shahram Amini
Department of Anesthesia, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran


| Amir Hooshang Mohammadpour
Department of Clinical pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
نشانی اینترنتی https://ajp.mums.ac.ir/article_20908.html
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نوع مقاله منتشر شده Original Research Article
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