Middle East Journal of Cancer، جلد ۱۴، شماره ۱، صفحات ۱۱۳-۱۱۸
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عنوان انگلیسی Effect of Zinc Sulfate on Overall Survival and Progression-Free Survival in Patients with Glioblastoma Multiforme, a Phase II Study
چکیده انگلیسی مقاله Background: Glioblastoma is the most prevalent and aggressive adult glial tumor. Patients who receive standard treatment have a mean survival of 12-14 months. Zinc is a micronutrient that has shown to have anticancerous effects. In the in vitro studies zinc had antineoplastic effects on gliobalstoma cells.Method: This is a phase II randomized trial in which 60 patients in two groups were evaluated. The zinc group (29 patients) received zinc sulfate supplement 50 mg orally twice a day and the control group (31 patients) who were selected from historical case sreceived no supplements.Results: Mean overall survival in the case and control groups were 9.93 (± 3.29) and 9.0 (± 3.56) months. In the case and control groups, the mean disease-free survival were 9.62 (SD ± 3.37) and 8.26 (SD ± 3.47) months. These differences were not statistically significant. Although overall survival and recurrence-free survival in patients in the case group was higher than the control group, there was no statistically significant difference (P = 0.485).Conclusion: Zinc consumption was associated with better survival, but these differences were not statistically significant, necessitating further studies.
کلیدواژه‌های انگلیسی مقاله Glioblastoma multiforme, Chemotherapy, Radiotherapy, Zinc sulfate
نویسندگان مقاله Niloofar Ahmadloo |
Radiation Oncology Department, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

Parisa Kameli |
Radiation Oncology Department, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

Mansour Ansari |
Breast Diseases Research Center, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

Ahmad Mosalaei |
Radiation Oncology Department, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

Shapour Omidvari |
Breast Diseases Research Center, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

Hamid Nasrollahi |
Radiation Oncology Department, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

Seyed Hassan Hamedi |
Radiation Oncology Department, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

Mohammad Mohammadianpanah |
Colorectal Research Center, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

نشانی اینترنتی https://mejc.sums.ac.ir/article_48458_26e6f1b4eaba5d142692394cbaaf2ec5.pdf
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