این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Middle East Journal of Cancer، جلد ۱۴، شماره ۱، صفحات ۴۱-۴۸
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی BMI-1 Gene Expression in Patients with Acute and Chronic Myeloid Leukemia in the Northeast of Iran
چکیده انگلیسی مقاله Background: The B-cell-specific Moloney murine leukemia virus integration site1 (BMI-1) is one of the famous members of the Polycomb ring finger group, which plays a crucial role in the gene transcription regulation through histone changes. Hence, it is believed to be necessary to further clarify the effects of the BMI-1 clinical.Method: This cross-sectional study was conducted on 70 acute myeloid leukemia (AML), 70 chronic myeloid leukemia (CML), and 20 healthy individuals, as the control group. We used real-time quantitative polymerase chain reaction in order to assess the BMI-1 level expression and its effect on prognosis in AML patients in the Molecular Pathology Research Center.Results: The results of the present work indicated that the BMI-1 overexpression was significantly higher in the AML and CML patients compared with that in the healthy controls (P < 0.001). Furthermore, a significant relationship was observed between the BMI-1 overexpression and poor prognosis in the AML patients (Hazard ratio=1.749, P < 0.001, 95% confidence interval = 1.31-2.32). Additionally, BMI- 1high was found in chronic and blastic phase in the CML patients (P < 0.001).Conclusion: We concluded that investigation of BMI-1 gene expression pattern will be conducive to the prognosis and treatment of myeloid leukemia.
کلیدواژه‌های انگلیسی مقاله BMI-1 gene, Acute, Myeloid, Leukemia, Chronic myeloid leukemia, Prognostic effect
نویسندگان مقاله Zahra Zafari |
Department of Hematology and Blood Bank, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Hossein Ayatollahi |
Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Tayebeh Sohrabi |
Department of Hematology and Blood Bank, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Pourya Arbab Jafari |
Department of Hematology and Blood Bank, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Habibollah Esmaeili |
Social Determination of Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Mohammad Reza Keramati |
Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

نشانی اینترنتی https://mejc.sums.ac.ir/article_47791_f19c7e3b90637bade5edd9327d506e2d.pdf
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات