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Infection Epidemiology and Microbiology، جلد ۷، شماره ۱، صفحات ۲۹-۳۵
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| عنوان انگلیسی |
Antibacterial Effect of Matricaria chamomilla Alcoholic Extract against Drug-Resistant Isolates of Staphylococcus aureus and Pseudomonas aeruginosa |
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| چکیده انگلیسی مقاله |
Background: This study aimed to determine antibacterial activity of ethanolic extract of Matricaria chamomilla (chamomile) against methicillin-resistant Staphylococcus aureus (MRSA) and multidrug-resistant (MDR) Pseudomonas aeruginosa strains isolated from clinical specimens. Materials & Methods: The plant samples were collected, and the flowers and leaves were separated and dried completely in the shade. After grinding, extraction was performed using the maceration method. The extracts of both flowers and leaves were dried at 37°C for 24 hrs. About 500 mg of the dried plant extract was dissolved in 10 mL of 5% dimethyl sulfoxide and sterilized by filtration through a 0.45 µm membrane filter. For the antibacterial assay, agar well diffusion and broth microdilution methods were used. Findings: No inhibitory effect was observed for both extracts against MDR P. aeruginosa isolates in agar well diffusion method. In broth microdilution method, the leaves extract showed inhibitory effect, and its MIC and MBC were determined at 12.5 and 25 mg/mL concentrations, respectively. The flowers extract showed antibacterial activity against most MRSA isolates. The extract of leaves demonstrated inhibitory effect on 7 MRSA isolates. The MIC and MBC of flowers extract were determined at concentrations of 6.25 and 12.5 mg/mL for most MRSA isolates, while MIC and MBC of leaves extract were 12.5 and 25 mg/mL for a few MRSA isolates, respectively. Conclusion: In this study, the ethanolic extract of chamomile leaves showed antibacterial activity against MDR P. aeruginosa isolates; meanwhile, the flowers extract showed better activity against MRSA isolates. |
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| کلیدواژه‌های انگلیسی مقاله |
Antibacterial effect, Drug-resistance, Matricaria chamomilla, Pseudomonas aeruginosa, Staphylococcus aureus. |
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| نویسندگان مقاله |
| Ania Ahani Azari
Department of Microbiology, Gorgan Branch, Islamic Azad University, Gorgan, Iran
| Ahmad Danesh
Infectious Diseases Research Center, Golestan University of Medical Sciences, Gorgan, Iran
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| نشانی اینترنتی |
http://iem.modares.ac.ir/browse.php?a_code=A-10-51934-8&slc_lang=en&sid=4 |
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| زبان مقاله منتشر شده |
en |
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