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Infection Epidemiology and Microbiology، جلد ۸، شماره ۳، صفحات ۰-۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Emergence of OXA-10 and OXA-48 Like Carbapenemases among Enterobacter Isolates from Inpatients in Namazi Hospital in Shiraz |
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| چکیده انگلیسی مقاله |
Backgrounds: The global spread of carbapenemase-producing Enterobacteriaceae represents a public health concern. This study aimed to investigate the prevalence of carbapenem resistance and the presence of some oxacillinase types and class 1-3 integrons among Enterobacter clinical isolates from an Iranian inpatient population. Materials & Methods: Ninety Enterobacter isolates from hospitalized patients were diagnosed by microbiological methods. Antibiogram pattern was also determined. The presence of class 1-3 integrons and four types of oxacillinase genes was assessed using PCR. Findings: Among 90 Enterobacter isolates, the most common species was E. aerogenes, (45.6%), followed by E. cloacae (30%). The highest resistance rate was against ampicillin (96.7%). Multi-drug resistance (MDR) was substantial (93%). Carbapenemase-producers were detected in 96% of carbapenem-resistant isolates by mCIM test. The frequency of evaluated genes was as follows: intI1 = 50 (55.6%), intI2 =12 (13.3%), blaoxa-1 =6 (6.7%), blaoxa-2 =5 (5.6%), blaoxa-10 =18 (20%), and blaoxa-48 =18 (20%). Conclusion: Determinants of class 1 integron along with OXA-10 and OXA-48 like carbapememases are responsible for relatively considerable carbapenem resistance among isolates. This is the first report about the presence of OXA-10 and OXA-48-producing Enterobacter spp. in Iran, indicating that the prevalence of oxacillinases in the country might be on the rise. |
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| کلیدواژه‌های انگلیسی مقاله |
Enterobacter, Carbapenemase, Oxacillinase, Integron, Iran |
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| نویسندگان مقاله |
| Melika Moradi
Department of Bacteriology and Virology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
| Reza Khashei
Department of Bacteriology and Virology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
| Yalda Malekzadegan
Department of Bacteriology and Virology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
| Jamal Sarvari
Department of Bacteriology and Virology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
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| نشانی اینترنتی |
http://iem.modares.ac.ir/browse.php?a_code=A-10-68538-1&slc_lang=en&sid=4 |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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