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Iranian Journal of Public Health، جلد ۵۱، شماره ۸، صفحات ۱۷۷۸-۱۷۸۹
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عنوان انگلیسی A Disintegrin and Metalloprotease 10 Expressions Modulate Potential Metastatic and Thrombus Formation in Pancreatic Carcinoma
چکیده انگلیسی مقاله Background: Clinical investigations repurposing a disintegrin and metalloproteases 10 (ADAM10) as metastatic and thrombus marker have achieved encouraging results, but the mechanism behind this association remains unclear. Methods: This study was carried out in NingXia and Wuhan, China from 2017 to 2021. The effects of ADAM10 expression on the metastatic and thrombus-associated genes: tissue factor (TF), P-selectin glycoprotein ligand-1 (PSGL-1), cathepsin G (CTSG) and mucin 1 (MUC1) were examined by immunofluorescence, qRT-PCR and Western blotting analysis. Metastatic and thrombotic behaviors were evaluated using NODSCID mouse model. Results: The ADAM10 expression controlled the migration and invasion of pancreatic carcinoma cell-1(PANC-1), and significantly regulated the metastatic and thrombus-associated genes (P＜0.05). ADAM10 and MUC1 were regulated and aberrantly expressed by a dependent mechanism. Moreover, ADAM10 expression induced the progression of adenocarcinoma cells and thrombus formation in vivo. Conclusion: Regulation of ADAM10 expression in cancer cells might effectively pave the way for a more potent anti-metastatic and anti-thrombotic approach and could regulate the invasion and migration of cancer cells.  
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نویسندگان مقاله | Miao Yu
Department of Vascular Surgery, General Hospital of Ningxia Medical University, Yinchuan, Ningxia 750004, China


| Quan Chen
Department of Vascular Surgery, Gansu Provincial Hospital, Lanzhou 730000, China


| Qin Li
Department of Vascular Surgery, :union: Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wu-han 430022, China


| Yunfei Teng
Department of Vascular Surgery, :union: Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wu-han 430022, China


| Lin Xiao
Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China


| Guang Yang
Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China


| Chenxi Ouyang
Department of Vascular Surgery, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking :union: Medical College, Beijing 100037, China


| Ahmed Mohammed Elamin Abdalla
1. Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China 2. Department of Biochemistry, College of Applied Science, University of Bahri, Khartoum 1660/11111, Sudan
نشانی اینترنتی https://ijph.tums.ac.ir/index.php/ijph/article/view/27670
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