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Iranian Journal of Public Health، جلد ۵۱، شماره ۶، صفحات ۱۲۲۳-۱۲۳۱
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عنوان انگلیسی Turmeric for Treatment of Irritable Bowel Syndrome: A Systematic Review of Population-Based Evidence
چکیده انگلیسی مقاله Background: Irritable bowel syndrome (IBS) is a highly prevalent disorder of the gut interaction characterized by abdominal discomfort and pain associated with altered bowel habits in the absence of structural abnormalities. In spite of IBS' high prevalence and disease burden across the globe, no explanations have been given as to its underlying pathophysiology. As for the treatment of IBS, there is no specific medication, and the most beneficial treatment is usually supportive therapy. Recent animal and human studies have demonstrated the therapeutic potential of curcumin or turmeric in the treatment of IBS. Methods: We systematically reviewed all available evidence supporting curcumin and turmeric's therapeutic potential in relieving IBS symptoms in the present study. For this purpose, a database search was performed using curcumin, turmeric, and IBS and all their equivalents as of the search terms in Web of Science, PubMed, Scopus, Ovid, Embase, and Google Scholar from1990 up to Feb 2021. The investigation was then limited to clinical trials, and then nine articles were collected for data analysis. Results: The findings of the included literature showed that curcumin and turmeric alone or in combination with other medications could improve the severity of IBS as well as the quality of life among people who suffer from IBS symptoms. Conclusion: Overall, medications containing curcumin and turmeric extract due to these compounds' anti-inflammatory effects may improve IBS symptoms, particularly abdominal pain and life quality.  
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نویسندگان مقاله | Emad Jafarzadeh
Department of Toxicology and Pharmacology, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran


| Shahram Shoeibi
Food and Drug Laboratory Research Center, Iran Food and Drug Administration, Ministry of Health and Medical Education, Tehran, Iran


| Yaser Bahramvand
Students’ Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran


| Elham Nasrollahi
Students’ Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran


| Armin Salek Maghsoudi
Department of Toxicology and Pharmacology, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran


| Fatemeh Yazdi
Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran


| Sepideh KarkonShayan
Student Research Committee, School of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran


| Shokoufeh Hassani
Toxicology and Diseases Group, Pharmaceutical Sciences Research Center, The Institute of Pharmaceutical Sciences, Tehran Uni-versity of Medical Sciences, Tehran, Iran
نشانی اینترنتی https://ijph.tums.ac.ir/index.php/ijph/article/view/26430
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