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Middle East Journal of Cancer، جلد ۱۳، شماره ۲، صفحات ۲۱۶-۲۲۵
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| عنوان انگلیسی |
Human Homeobox TGIFLX Regulates CDX1, CDX2, and OCT1 Genes Expression in Colorectal Cancer Cell Lines |
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| چکیده انگلیسی مقاله |
Background: Homeodomain transcriptional regulatory proteins, which are encoded by Homeobox (HOX) genes, play critical roles in both normal development and carcinogenesis. Previous studies have shown that the expression of HOX genes is deregulated in numerous tumors and this expression is specific to each cancer based on the arising embryonic origin tissue and the site of tumor. Method: In this in vitro study, the expression levels of HOXA10, CDX1, CDX2, TGIFLX, TGIFLY, and OCT1 genes were compared across 10 different human colorectal cancer cell lines with different differentiation stages. Subsequently, the effect of TGIFLX siRNA-mediated knockdown on the expression levels of CDX1, CDX2, and OCT1 genes was analyzed in SW948 cell line. Results: The obtained results revealed that these homeobox genes were differentially expressed in different colorectal cancer cell lines. Furthermore, the siRNA-mediated knockdown of TGIFLX led to higher levels of CDX1, CDX2, and OCT1 expression. Conclusion: Our data suggested that TGIFLX plays an important role in the upstream regulation of CDX1, CDX2, and OCT1 genes. |
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| کلیدواژه‌های انگلیسی مقاله |
Colorectal neoplasms, Homeobox genes, RNA, Small interfering, Mutation |
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| نویسندگان مقاله |
Soroosh Shahryarhesami |
Department of Medical Genetics, Tehran University of Medical Sciences, Tehran, Iran
Mansour Heidari |
Department of Medical Genetics, Tehran University of Medical Sciences, Tehran, Iran
Masoud Heidari |
Department of Animal Biology, Faculty of Natural Sciences, Tabriz University, Tabriz, Iran
Nahid Sadighi |
Cancer Research Center, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, Iran
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| نشانی اینترنتی |
https://mejc.sums.ac.ir/article_47623_fe48601a9be70c4689680438374f947b.pdf |
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| زبان مقاله منتشر شده |
en |
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